Objectives Caralluma is a xerophytic genus used as traditional medicine for the treatment of diabetes, inflammation, leprosy, obesity and rheumatism. Objectives of this review are to establish a relationship between traditional uses and scientific studies by critically evaluating the available fragmented literature on ethnobotany, pharmacology, phytochemistry and toxicology of genus Caralluma. Key findings Ethnomedical uses of Caralluma have been recorded from various countries such as China, India, Iran and Pakistan for six major classes of diseases including diabetes and gastrointestinal disorders. This review indicated the efficacy of genus Caralluma in several in vitro and in vivo pharmacological properties such as antimicrobial, antioxidant and anticancer activity. These bioactivity might be due to the presence of certain classes of compounds in genus Caralluma including pregnane glycosides, flavonoid glycosides and flavones. Summary Traditional uses and scientific evaluation of Caralluma indicates that it is one of the most widely used genus in some parts of the world. Further studies on the structural activity relationship of some of the isolated compound may improve their biological potency as well as scientific exploitation of traditional uses of the genus.
Raphanus sativus (Radish) is a widely used vegetable belonging to the family Brassicaceae, generally grown as annual or biennial plants, with a taproot which is much enlarged when it is cultivated. In Yemenite folk medicines, R. sativus juice is used in eliminating kidney stones. Few people, specifically in the Middle East, prefer to drink its juice in pursuit of certain health benefits. In Unani, Greeko-Arab, and Indian folk medicine, It is used as a home remedy for the treatment of many diseases such as jaundice, gallstone, liver diseases, rectal disorder, indigestion, and other gastric pains. This article has reviewed the information available on R. sativus ethnopharmacology, geographical distribution, chemical composition, and pharmacological uses. The information on botanical description, distribution, traditional uses, chemical composition, bioactive components, and therapeutic investigations was gathered from a comprehensive literature search of electronic databases such as Science Direct, PubMed, Web of Science, Wiley, ACS, Springer, Google Scholar, and SCOPUS until 2020 for publications. An elaborative study has been done on botanical characterization, traditional uses, chemical composition, and various pharmacological or therapeutic uses. Mainly this plant is fully loaded with polyphenolic compounds which exert a promising antioxidant property. This plant possesses various therapeutic benefits such as anti-inflammatory, anti-microbial, anti-tumorogenesis, anti-cancer, anti-diabetic, and anti-nephrotoxicity activity. The comprehensive literature analysis shows that a wide range of populations has utilized various parts of R. sativus around the globe. The above information shows that the plant holds a variety of hidden and unknown potentials which can be studied extensively for its phytoconstituents and therapeutic outcomes. However, while searching through the literature available, it was observed that there is a lack of information on its phytochemical profiling and its corresponding pharmacological benefits. It is believed that this review will help lay the groundwork for encouraging pharmacological and pharmaceutical studies.
Purpose: To pharmacologically investigate the methanol and petroleum ether extracts of the plant leaves of Manilkara zapota (MZME and MZPE, respectively), Abroma augusta (AAME and AAPE, respectively) and Vitex negundo (VNME and VNPE, respectively (highest protection: 80.3 %, p < 0.05) and VNME (lowest protection: 38.6 %, p < 0.001). The extracts demonstrated CNS depressant activity in a dose-dependent manner (p < 0.05 compared to the standard except for AAME and AAPE which showed insignificant activity). Conclusion:The results indicate that the traditional use of the investigated plants appears to be justified; however, further studies are required to unravel the underlying mechanisms of action.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.