Entada rheedi is claimed to have antistress activity by folklore which is available abundantly in several places of India. The present study was planned to evaluate the phytochemical, anti-oxidant, anti-stress and cerebroprotective activities of ethyl acetate extract of bark of Entada rheedi (EAER). The bark of Entada rheedi was collected and extracted with ethyl acetate. The ethyl acetate extract was subjected to phytochemical screening (chemical and HPTLC), antioxidant (in-vitro), anti-stress (mice model) and cerebroprotective activities (cerebral ischemia model). EAER showed the presence of flavonoids as primary phytoconstituents. EAER significantly reduced the immobility time in swimming endurance and tail suspension test. EAER significantly reduced the TBARS levels and augmented tissue antioxidants in restraint stress model and cerebral ischemia model. The levels of MOA-A were reduced in the EAER treated animals and cortisol levels also reduced in EAER treated animals. Histopathology also supported the biochemical parameters. The EAER effect was compared with reference standard diazepam and Ashwagandha. EAER showed significant antioxidant, anti-stress and cerebroprotective activities and the protective effect could be due to the presence of flavonoids as phytoconstituents.
The current study was designed to assess the phytochemical, antioxidant, anti-stress and cerebroprotective activities of ethanolic extract of stem of Sarcostemma acidum (EESA). The stem of Sarcostemma acidum was collected and extracted with 70% ethanol. The ethanolic extract was subjected to phytochemical screening (Chemical and HPTLC), antioxidant (in-vitro), anti-stress (Mice model) and cerebroprotective activities (Cerebral ischemia model). EESA showed presence of flavonoids as primary phytoconstituents. EESA significantly reduced the immobility period in tail suspension trial and swimming endurance trial. EESA significantly reduced the TBARS levels (21.45±0.56; p<0.01) and augmented tissue antioxidants in cerebral ischemia model. The levels of MOA-A were reduced in the EESA treated animals (54.1±0.2; p<0.001) and cortisol levels also reduced in EESA treated animals (45.1±1.6; p<0.001). Histopathology also supported the biochemical parameters. The EESA effect was compared with reference standard diazepam and Ashwagandha. EESA showed significant antioxidant, anti-stress and cerebroprotective activities and the protective effect might be due to presence of flavonoids as phytoconstituents.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.