BACKGROUNDThyroid disorders are common endocrine disorders. Thyroid function tests which are usually done are measurement of blood levels of hormones Triiodothyronine (T3), Thyroxine (T4) and Thyroid Stimulating Hormone (TSH), which are affected by various nonspecific conditions. Therefore, the present study is done to evaluate the role of additional biochemical parameter Creatine Kinase (CK) in diagnosing hypothyroidism. Thyroid function and Creatine Kinase activity was measured in 70 patients with clinically suspected cases of hypothyroidism. Patients with hypothyroidism will have decreased T3, T4 levels and increased levels of TSH. However, whether there is any correlation of Creatine Kinase with hypothyroidism is not well established. In our study, we found that in hypothyroid patients there is significant increase in CK levels. Measurement of CK levels is an additional biochemical parameter to diagnose hypothyroidism.
OBJECTIVESChronic Obstructive Pulmonary Disease (COPD) is one of the commonest causes of mortality and morbidity in our country. The habit of smoking, increasing air pollution and other environmental factors facilitate the occurrence of this condition. COPD causes pulmonary hypertension through several inter-related mechanisms including hypoventilation, hypoxemia from ventilation perfusion mismatch and destruction of perfused surface area. The altered haematological and hemo-rheological factors also contribute to the development of pulmonary hypertension in COPD. Our study aims at correlating ECG and Echocardiographic findings with the severity of COPD. METHODSOur study was conducted at a tertiary hospital in Bangalore. We studied 61 patients, among them 21 were mild COPD, 20 were moderate COPD and 20 patients belonged to severe COPD patients. Patients with COPD as defined by ATS (American Thoracic Society) were studied. The lung function parameters were assessed by Spiroanalyser (Vitalograph). They were categorised into mild, moderate and severe COPD based on the percentage of predicted FEV1. All of them underwent detailed clinical examination, ECG, Echocardiography and routine investigations. RESULTSThe mean age of all patients was 61.11±10.51 years and majority 85.25% were males. The most common ECG finding observed in all the groups was 'P' pulmonale [28.57%, 40%, 45% in mild, moderate and severe COPD respectively]. The mean RV area, RA area, RVAWT were 14.26±4.82cm 2 , 7.98±1.97cm 2 and 0.61±0.18cms; 19.19±6.02cm 2 , 10.68±3.45cm 2 and 0.83±0.17cms; and 23.43±5.83cm 2 , 13.58±3.18cm 2 and 0.91±0.18cms in mild, moderate and severe COPD patients respectively.
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