The parasagittal (PS) plane is a 2-D diagnostic plane used routinely in cranial ultrasonography of the neonatal brain. This paper develops a novel approach to find the PS plane in a 3-D fetal ultrasound scan to allow image-based biomarkers to be tracked from prebirth through the first weeks of postbirth life. We propose an accurate plane-finding solution based on regression forests (RF). The method initially localizes the fetal brain and its midline automatically. The midline on several axial slices is used to detect the midsagittal plane, which is used as a constraint in the proposed RF framework to detect the PS plane. The proposed learning algorithm guides the RF learning method in a novel way by: 1) using informative voxels and voxel informative strength as a weighting within the training stage objective function, and 2) introducing regularization of the RF by proposing a geometrical feature within the training stage. Results on clinical data indicate that the new automated method is more reproducible than manual plane finding obtained by two clinicians.
10 Hz and the amplitude set at equal to the MAP value at the beginning, was increased, if necessary, until the infant's chest was seen to be "bouncing". In the HFOV+VG mode, the VThf was set at 2 ml/kg initially on the basis of our clinical experience. The Amplitude limit was set at 15-20% above the average amplitude needed to achieve the target VTHf. Moreover during each 2 h observation period, the following variables were continuously display at 5-min intervals: FiO2, MAP, VThf, Carbon dioxide diffusion co efficiency (DCO2), Amplitude (DeltaPhf), from the ventilator records and heart rate, mean blood pressure, SpO2 from the standard cardiorespiratory monitor. Results The mean gestational age was 28,2 (24-32) week and the mean gestational weight was 1087 (704-1960) gr. There was no significant difference in the mean PCO2, FiO2, DeltaPhf, MAP, VTHf, DCO2, Minute ventilation (MVe), Dynamic compliance (CDyn), Resistance (R). Hypocarbia event (PCO2 <40 mmHg) occurred eleven (%36) sample during HFOV+VG period against seven sample (%23) during HFOV period but not statistical significant. Conclusion This preliminary result demonstrated that VG option, when combined with HFOV, a stable and feasible ventilation mode for neonatal patients and can achieve equivalent gas exchange After a careful analysis of the results, a set VTHf of 1,5 ml/kg seems to be successful achieving equivalent gas exchange using lover airway pressure. Background Hypothermia isgenerally thought to be a risk factor of respiratory distress syndrome (RDS) in premature infants. However, previous studies have primarilyinvestigated the association between hypothermia and death. Aim To investigate the association between body temperature and severe RDS. Methods The study population consists of all infants born before 32 weeks of gestationand admitted to the neonatal intensive care unit (NICU), Aalborg UniversityHospital, Denmark April 1997 and December 2011. Rectal temperature was measuredat admission. Severe RDS was defined as the need for surfactant treatment or death within the first 3 days of life in premature infants bornbefore 32 weeks gestation. Data are provided bynational registries and will be analysed by logistic regression while adjusting formarkers of infection, gestational age, time from delivery to admission, asphyxiaand a proxy variable for fetal growth restriction. Results Preliminary results from 593 infants show that64% (n = 381) had hypothermia (< 36. Background and aim Inhaled corticosteroids reduce lung inflammation in chronic lung disease (CLD) and may be safer than systemic dexamethasone treatment, but evidence of better efficacy is lacking. State-of-the-art aerosol delivery systems may permit enhanced alveolar steroid delivery compared with traditional metered-dose inhalers/spacers or jet nebulisers. We evaluated a new-generation electronic micropump vibrating-mesh nebuliser for topical airways delivery of budesonide in infants with severe CLD requiring nasal high-flow respiratory support. Methods We reviewed our units' clinical...
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