Anika Buehler scite author profile

Background:The British precursor protein (BRI2) influences amyloid precursor protein metabolism. Results: BRI2 lowers ␤-amyloid peptide levels by increasing levels of secreted insulin-degrading enzyme (IDE) in both cells and mice. Conclusion: BRI2 as a receptor protein regulates IDE levels and in turn promotes ␤-amyloid degradation. Significance: Targeting the regulation of IDE may lead to new approaches to therapeutically address sporadic Alzheimer disease.

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P4‐689: INACTIVATION OF PATHOGENIC Aβ SEEDS AT PRE‐AMYLOID DISEASE STAGES

Uhlmann

Rasmussen

Rother

et al. 2019

Alzheimer's & Dementia

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Anika Buehler

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE)

P4‐689: INACTIVATION OF PATHOGENIC Aβ SEEDS AT PRE‐AMYLOID DISEASE STAGES

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