Background: ABO and rhesus blood group study is very relevant to the blood transfusion services policy maker and clinicians. ABO and rhesus blood group are the most prevalent blood groups among so many other blood groups discovered. Aims: The aim of this study was to find out the current distribution of ABO and Rh blood groups among the blood donors in city of Enugu. Study Design: Two hundred and ninety randomly selected male and female blood donors were grouped according to their ABO and Rh blood group.