The first-passage-time p.d.f. through a time-dependent boundary for one-dimensional diffusion processes is proved to satisfy a new Volterra integral equation of the second kind involving two arbitrary continuous functions. Use of this equation is made to prove that for the Wiener and the Ornstein–Uhlenbeck processes the singularity of the kernel can be removed by a suitable choice of these functions. A simple and efficient numerical procedure for the solution of the integral equation is provided and its convergence is briefly discussed. Use of this equation is finally made to obtain closed-form expressions for first-passage-time p.d.f.'s in the case of various time-dependent boundaries.

The first-passage-time p.d.f. through a time-dependent boundary for one-dimensional diffusion processes is proved to satisfy a new Volterra integral equation of the second kind involving two arbitrary continuous functions. Use of this equation is made to prove that for the Wiener and the Ornstein-Uhlenbeck processes the singularity of the kernel can be removed by a suitable choice of these functions. A simple and efficient numerical procedure for the solution of the integral equation is provided and its convergence is briefly discussed. Use of this equation is finally made to obtain closed-form expressions for first-passage-time p.d.f.'s in the case of various time-dependent boundaries

The first-crossing-time problem through two time-dependent boundaries for one-dimensional diffusion processes is considered. The first-crossing p.d.f.'s from below and from above are proved to satisfy a new systems of Volterra integral equations of the second kind involving two arbitrary continuous functions. By a suitable choice of such funcitons a system of continuous-kernel integral equations is obtained and an efficient algorithm for its solution is provided. Conditions on the drift and infinitesimal variance of the diffusion process are given such that the system of integral equations reduces to a non-singular single one

Motivated by some as yet unsolved problems of biological interest, such as the description of firing probability densities for Leaky-and-Integrate neuronal models, we consider the first-passage-time problem for Gauss-diffusion processes along the line of Mehr and McFadden (1965). This is essentially based on a space-time transformation, originally due to Doob (1949), by which any Gauss-Markov process can expressed in terms of the standardWiener process. Starting with an analysis that pinpoints certain properties of mean and autocovariance of a Gauss-Markov process, we are lead to the formulation of some numerical and time-asymptotically analytical methods for evaluating first-passage-time probability density functions for Gauss-diffusion processes. Implementations for neuronal models under various parameters choices of biological significance confirms the expected excellent accuracy of our methods

The first-crossing-time problem through two time-dependent boundaries for one-dimensional diffusion processes is considered. The first-crossing p.d.f.'s from below and from above are proved to satisfy a new system of Volterra integral equations of the second kind involving two arbitrary continuous functions. By a suitable choice of such functions a system of continuous-kernel integral equations is obtained and an efficient algorithm for its solution is provided. Finally, conditions on the drift and infinitesimal variance of the diffusion process are given such that the system of integral equations reduces to a non-singular single integral equation for the first-crossing-time p.d.f.

A model is proposed to describe the spike-frequency adaptation observed in many neuronal systems. We assume that adaptation is mainly due to a calcium-activated potassium current, and we consider two coupled stochastic differential equations for which an analytical approach combined with simulation techniques and numerical methods allow to obtain both qualitative and quantitative results about asymptotic mean firing rate, mean calcium concentration and the firing probability density. A related algorithm, based on the Hazard Rate Method, is also devised and described.

The leaky integrate-and-fire neuronal model proposed in Stevens and Zador (1998), in which time constant and resting potential are postulated to be time dependent, is revisited within a stochastic framework in which the membrane potential is mathematically described as a gauss-diffusion process. The first-passage-time probability density, miming in such a context the firing probability density, is evaluated by either the Volterra integral equation of Buonocore, Nobile, and Ricciardi ( 1987 ) or, when possible, by the asymptotics of Giorno, Nobile, and Ricciardi (1990). The model examined here represents an extension of the classic leaky integrate-and-fire one based on the Ornstein-Uhlenbeck process in that it is in principle compatible with the inclusion of some other physiological characteristics such as relative refractoriness. It also allows finer tuning possibilities in view of its accounting for certain qualitative as well as quantitative features, such as the behavior of the time course of the membrane potential prior to firings and the computation of experimentally measurable statistical descriptors of the firing time: mean, median, coefficient of variation, and skewness. Finally, implementations of this model are provided in connection with certain experimental evidence discussed in the literature.

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