Introduction: Currently, Vietnam is entering the aging population stage and is one of the fastest aging countries worldwide. Old age increases the risk of chronic diseases, particularly mental health disorders. Objective: investigated the prevalence of depression and examined the associated factors with depression among older people. Methods: A cross-sectional study was implemented in 760 older people in some communities of Thua Thien Hue province from January to August 2020. Data were collected by directinterviewing based on a structured questionnaire, including demographic, socio-economic, geriatric Depression scale with 30 questions (GDS-30), health status and physical activities. The GDS-30 was used to evaluate the prevalence of depression. The multiple logistic regression model was applied to exam the associated factors with depression. Results: Our findings indicated that the prevalence of depression among elderly people was 28.6%, comprising mild (23.6%) and seveve (5%). The higher Odds of depression was observed in the low economic status (poor/near-poor) (OR= 2.51; 95% CI: 1.15 – 5.48), live alone (OR= 2.43; 95% CI: 1.02-5.78), co-morbidities chronic disease(OR =1,59; 95% CI: 1.01 – 2.52), self-evaluation not good in overall health status (OR =2.34; 95% CI: 1,50 – 3,66), dissatisfaction in health (OR = 2.55; 95% CI:1.59 – 4.08), lack of physical activities (OR =2.79; 95% CI: 1.83 - 4.27), and low quality of life (OR = 2.79; 95% CI: 1.84-4.24). Conclusions: This research suggests that older people are commonly exposing to depression in the communities. Therefore, the priority strategies for reducing depression should be implemented, particularly in the high-risk groups.
Background (including purposes): Periodontitis is a chronic bacterial infection destroying tooth supporting tissues. Although metronidazole exhibits a high effectiveness in the periodontitis treatment, its fast release and the usage frequency of several times per day can become obstacles for the local treatment. Therefore, nanotechnology is necessary to extend the duration of action and reduce the frequency of drug usage per day. The aim of this study was to formulate metronidazole nanoparticles by the nanoprecipitation method and to evaluate their physicochemical properties.
Materials and methods: Metronidazole, Eudragit RS100 polymer were used in this study. Nanoparticles containing metronidazole were prepared by the nanoprecipitation method. The factors of the formulation and manufacturing process of nanoparticles containing metronidazole were investigated. The resulting nanoparticles were characterized in terms of the particle size, polydispersed index (PDI), encapsulation efficiency, etc.
Results: The nanoparticles containing metronidazole were successfully prepared with the spherical shape, the particle size of 201.9 ± 5.6 nm, PDI of 0.092 ± 0.014, and entrapment efficiency of 46.28 ± 1.18%. These nanoparticles could prolong the drug release (53.45 ± 1.49% at 24 hours). The Korsmeyer-Peppas equation best described the release kinetics of the drug from metronidazole nanoparticles.
Key words: Metronidazole, nanoparticle, periodontitis
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