<h1 align="left">ABSTRACT</h1><p><strong>Background</strong> : DM is a chronic disease that has long-term complications. Alloxan is a fast way to produce experimental diabetic (hyperglycemic) in animal experiments related to elevated LDL. Jeruju (<em>Acanthus ilicifolius</em>) is a low-growth herbaceous plant that easily grows containing secondary metabolites such as Alkaloids, Saponins, Flavonoids, Terpenoids, and Phenols.</p><p><strong>Objective</strong> : To determine the effect of jeruju leaf extract on the decrease in blood levels of LDL of male Wistar rat (<em>Rattus norvegicus</em>) induced Alloxan.</p><p><strong>Methods</strong> : This research is an experimental laboratory type with Post Test Only Control Group Design. The sample using 24 rats, which were divided into 3 groups: negative control group (K-) were given standard feed; positive control group (K +) induced alloxan 120 mg/kgBW on 1<sup>st</sup> day; the treatment group (P) induced alloxan 120 mg/kgBW on 1<sup>st</sup> day and was given jeruju leaf extract 67.2 mg/kgBW on 5<sup>th</sup>-14<sup>th</sup> day. The 15<sup>th</sup> day a blood sample was taken to determine LDL levels.</p><p><strong>Result</strong> : The results of One-Way ANOVA test showed an insignificant mean difference (p = 0.270) in LDL level of K- (<strong> </strong>= 9.75 mg/dl) and the K+ (<strong> </strong>= 11.38 mg/dl ). Insignificant mean difference (p = 0.270) in P (<strong> </strong>= 9 mg/dl) with blood LDL levels in the K+ (<strong> </strong>= 11.38 mg/dl) and the K- (<strong> </strong>= 9, 75 mg/dl).</p><p><strong>Conclusion</strong> : Giving alloxan can increase blood levels of LDL and administration of jeruju leaf extract can reduce blood levels of LDL in experimental animals but not statistically significant.</p><p><strong> </strong></p><strong>Keywords</strong>: Alloxan, LDL, <em>Acanthus ilicifolius</em>.
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