Although very difficult to define, happiness is becoming a core concept within contemporary psychology and affective neuroscience. In the last two decades, the increased use of neuroimaging techniques has facilitated empirical study of the neural correlates of happiness. This area of research utilizes procedures that induce positive emotion and mood, and autobiographical recall is one of the most widely used and effective approaches. In this article, we review eight positron emission tomography and seven functional magnetic resonance imaging studies that have investigated happiness by using autobiographical recall to induce emotion. Regardless of the neuroimaging technique used, the studies conducted so far have shown that remembering happy events is primarily associated with the activation of many areas, including anterior cingulate cortex, prefrontal cortex, and insula. Importantly, these areas are also found to be connected with other basic emotions, such as sadness and anger. In the conclusion, we integrate these findings, discussing important limitations of the extant literature and suggesting new research directions.Keywords Happiness . Autobiographical recall . PET . fMRI . Mood induction methodsDefining happiness is a difficult task for natural and social scientists, including psychologists, economists, sociologists, geneticists, and neuroscientists. Indeed, happiness is a term often used to refer to and that is interchangeable with many other concepts, such as well-being, flourishing, optimal functioning, life satisfaction, quality of life, and health

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Developmental topographical disorientation (DTD) has been defined as a developmental deficit in human navigational skills in the absence of congenital or acquired brain damage. We report the case of Lost In Space Again (LISA), a 22-year-old woman with a normal development and no clinical history of neurological or psychiatric diseases, evaluated twice, with an interval of 5 years. The magnetic resonance imaging (MRI) examination did not reveal any morphological alteration, while diffusion tensor imaging (DTI) showed a structural connectivity deficit (a decreased fractional anisotropy—FA) in the parieto–prefrontal and parieto–premotor pathway. The behavioral assessment showed different deficits in spatial and navigational tasks, which seemed to be connected to a poor ability to form a cognitive map of the environment. Moreover, LISA displayed a poor performance in high-level face encoding and retrieval. The aim of this case report is to share new insight about DTD in order to deepen the knowledge of this specific neurodevelopmental disorder. In conclusion, this novel DTD case (1) supports the hypothesis of the existence of different DTD subtypes; (2) sustains the evidence that DTD can co-occur (or not) with deficit in face recognition; and (3) highlights the need for an in-depth examination from both a neurocognitive and behavioral point of view of a possible common developmental defect between the formation of cognitive maps and the recognition of faces that might be in mental imagery skills. Future directions will be also discussed.

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