Board" and individualizing cognitive activities to the individual's interests and values. Conclusions: This study demonstrates successful facilitation and real world examples of person-centered care in hospitalized older adults with delirium superimposed on dementia. Person-centered care is an important goal in designing interventions for Alzheimer's and related dementias, but lacks a strong evidence base. Increased understanding of this approach may lead to better quality of care and improved management of delirium in persons with dementia.
P2-165 SUPPRESSION OF NF-kB SIGNALING PATHWAY BY LYCOPENE CAN PREVENT INSULIN RESISTANCE-ASSOCIATED COGNITIVE DEFICITSAnand Kamal Sachdeva 1 , Kanwaljit Chopra 2 , 1 UIPS, Panjab University, Chandigarh, Chandigarh, India; 2 Univ Inst Pharm Sci, Panjab University, Chandigarh -160 014, Chandigarh, India. Contact e-mail: anandkamalsachdeva@gmail.comBackground: Growing evidence supports the concept that Alzheimer's disease is fundamentally a metabolic disease. Epidemiological studies on cognitive impairment in patients with diabetes found evidence of cross sectional and prospective associations between type 2 diabetes and moderate degree of cognitive impairment, both for memory and executive functions. Several studies suggest that consumption of a fat rich diet leads to peripheral insulin resistance and impedes cognitive performance. Thus, the present study was designed to elucidate the role of NF-kB pathway in neuroprotective effect of lycopene in an experimental paradigm of insulin resistance in rats. Methods: Six-week-old male Wistar rats were fed with 15% fructose in drinking water for 24 weeks. Body mass, food and water intakes were measured regularly as well as plasma insulin levels, blood glucose levels, glycosylated heamoglobin levels, HOMA-IR levels and lipid profile levels were measured to ensure development of insulin resistance. Insulin resistance associatedcognitiveimpairment was measured by using Morris water maze test (computer tracking using EthoVision software) and elevated plus maze on 24 th week. Treatment with lycopene (1, 2 and 4 mg/kg) was initiated after 6 th week of fructose administration and continued till end of the study. At the end of study, animals were sacrificed for estimating biochemical and molecular parameters. Results: Insulin resistance was evident at 6 th week and persisted till end of study (24 th week) as demonstrated by significantincrease in body weight, plasma insulin levels, blood glucose levels, glycosylated heamoglobin levels, HOMAIRlevelsand deranged lipid profile.Cognitive deficit was significantly evident at 24 th weeks. Fructose-induced neuronal deficits were coupled with significant alterations in oxidative-nitrodative stress along with suppression of NF-kB and its downstream mediators as TNF-a, TGF-b 1, caspase-3 and IL-1b levels. Treatment with lycopene (1, 2 and 4 mg/kg) dose-dependently ameliorated emergence of insulin resistance-induced memory impairment along with mitigation of oxido-nitrosative stress mediated alterations...
