The Latin American immigrant population in Spain is growing year after year. The aim of this study is to describe how religious coping mechanisms, religiosity, acculturation and social support act in the prediction of happiness within the group of Latin American immigrants with Christian beliefs in Spain. Previous studies indicate that religious practice can be a factor that favors the perception of well-being and happiness in people. It is considered that the existence of close sources of support act as a key resource in facing stressful situations. A questionnaire consisting of 36 items was administered to a sample made up of 206 subjects of different Latin American nationalities who were going through a migration process. It was observed that religiosity, social support, religious coping mechanisms and gender were related to the perception of happiness. The results underline the importance of considering religiosity and social support together while intervening to improve the perception of happiness of Latin American immigrants in Spain.