No abstract

Gender differences in the epidemiology, comorbidities, and treatment responses of substance abuse have been described in adults. However, a growing body of data suggests that gender differences also exist in adolescents with substance abuse. Unfortunately, research is still limited in this age group. This article reviews gender differences in the diagnosis, presentation, course of illness, and treatment response of substance abuse in adults and adolescents. Adolescent substance abuse treatments that take into account these gender differences are also discussed.

The occurrence of depression is higher in females after puberty, suggesting a gender-related difference. This article reviews studies that have examined gender differences in the presentation and treatment of depression in adults and discusses how this information applies to depressed children and adolescents. The adult literature suggests that men and women vary in presentation of depression. In addition, differences exist in the pharmacokinetic properties of various medications, but it is unclear how they affect clinical treatment response. Studies of gender differences in child and adolescent depression are limited. Some studies suggest that differences seen in adults may also apply to children and adolescents. Studies of gender differences in treatment response are not available, however. Further study and evidence-based exploration are required to better understand gender differences in depression in children and adolescents.

Suicidal behavior (ie, thoughts and attempts) in children is an issue of serious concern. In the past, suicide in young children has been largely denied and ignored. However, this is no longer possible, as accumulating evidence supports the existence of suicidal thoughts and actions in preadolescent children. This article explores suicidal behavior in preadolescent children and highlights areas of needed research.