Starting
from readily available homochiral Vince lactam, trisubstituted
cyclopentanes were obtained utilizing conjugate addition of alkyl
cuprates as an efficient approach to introduce different side chains.
Although the 1,4-conjugate addition reactions gave the products as
mixtures of diastereomers, an epimerization approach followed by crystallization
furnished the stereoisomerically pure cyclopentanes.
Sample ID
Compound nameProject name Sample Information SN1033302520 AZ13468845 sPLA2x Analytical Conditions Column Dimensions (mm) Particle Size (μm) Mobile Phase Flow (ml/min) Detection (nm) Temperature (C) Comment t-Bu CQN 4.6 * 250 mm 10 ACN/IPA/HOAc 90/10/0.3 RT PDA 230.0 nm 1 ml/min Retention Time Area Area % K' N USP Resolution
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