3-Arylidenechroman-4-ones
and 2-arylidene-1-tetralones are hydrogenated
to cis-benzylic alcohols in dr’s and er’s
up to 99:1 via a CC and CO one-pot reduction in the
presence of 2–5 mol % Noyori–Ikariya-type RuII chiral complexes and HCO2Na as a hydrogen source under
asymmetric transfer hydrogenation–dynamic kinetic resolution
(ATH-DKR) conditions. The oxidation of theses substrates resulted
in the enantioselective synthesis of the natural homoisoflavanone
dihydrobonducellin and its carba-analogues.
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