Solid evidence underlines the pivotal role played by inflammation regarding atherosclerosis. Peripheral artery disease (PAD) is one of atherosclerotic cardiovascular diseases (CVDs), it is highly frequently diagnosed in older individuals. In the present study we carried out an investigation on the association between platelet-to-lymphocytes ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-HDL cholesterol ratio (MHR) with PAD as favourable markers. We identified 300 subjects aged over 70 years, without any concomitant CVDs. The PLR, NLR and MHR were assessed from peripheral venous blood routinely drawn in the ward during hospitalization. Patients were divided in groups according to ankle brachial index (ABI) value (>0.9; 0.9-0.99; 1-1.4; >1.4). Higher PLR (P= 0.007), NLR (P= 0.0001) and MHR (P=0.0001) were associated with <0.9 ABI. Patients with a >1.4 ABI showed NLR values higher compared to >0.9l ABI (P<0.01). Univariate linear regression analysis demonstrated the direct correlation between increase in PLR (P= 0.0023) and MHR (P<0.0001) with the decrease in ABI value. In multivariate linear regression analysis including main cardiovascular risk factors we found that PLR, NLR and MHR were independently associated with lower ABI (P=0.0011). Resultsshow and suggest that the elevated PLR, NLR and MHR are related to PAD evaluated with ABI measurement. PLR and MHR seem to be more reliable markers than NLR in PAD. NLR seems to be more related to incompressibility of arterial wall. It is hypothesized that these three indexes may play a role as simple and repetitive markers of PAD.
NAFLD is associated with unhealthy lifestyle and obesity, without alcohol habits. An association of NAFLD with coronary artery disease and with impaired heart function was reported, but without considering severity of NAFLD and with the bias of including diabetes.Aimto challenge if severity of liver steatosis assessed by UltraSound Bright Liver Score (BLS) can predict the impairment of systolic heart function, assessed by echocardiography(Ejection Fraction, EF). Age, obesity, dietary profile (assessed as Adherence to Mediterranean Diet Score, AMDS) and Insulin resistance (assessed by HOMA) were all taken into account for their confounding and synergic effect. 184 NAFLD (m 85, f 99; yrs 52.16±12.05) and 316 non‐NAFLD (m 104, f 212; yrs 48.27±16.32) non‐diabetic subjects were studied. By odds ratio NAFLD (OR 1.652, CI 95% 0.898–3.039), insulin resistance (OR 1.892, CI 95% 0.994–3.601) and overweight‐obesity (OR 2.137, CI 95% 1.137–4.016)were all associated with hazards of lower EF. A Multiple Linear Regression Model, age balanced for this confounding factor, confirms the predictivity (p<0.0001) of NAFLD severity, assessed by BLS, toward lower EF, along with BMI, AMDS and HOMA, with a variance of 8.5%.Conclusionlower systolic efficiency of heart assessed by echocardiography is strongly associated with the severity of NAFLD and unhealthy dietary profile in non‐diabetic subjects.
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