Background and Purpose: Distal medium vessel occlusions (DMVOs) are increasingly considered for endovascular thrombectomy but are difficult to detect on computed tomography angiography (CTA). We aimed to determine whether time-to-maximum of tissue residue function ( Tmax ) maps, derived from CT perfusion, can be used as a triage screening tool to accurately and rapidly identify patients with DMVOs. Methods: Consecutive code stroke patients who underwent multimodal CT were screened retrospectively. Two experienced readers evaluated all patients’ Tmax maps in consensus for presence of delay in an arterial territory (territorial Tmax delay). The diagnostic accuracy of this surrogate for identifying DMVOs was determined using receiver-operating characteristic analysis. CTA, interpreted by 2 experienced neuroradiologists with access to all imaging data, served as the reference standard. Diagnostic performance of 4 other readers with different levels of experience for identifying DMVOs on Tmax versus CTA was also assessed. These readers independently assessed patients’ Tmax maps and CTAs in 2 separate timed sessions, and areas under the receiver-operating characteristic curves were compared using the DeLong algorithm. The Wilcoxon signed-rank test was used to comparatively assess diagnostic speed. Results: Three hundred seventy-three code stroke patients (median age, 70 years; 56% male, 70 with a DMVO) were included. Territorial Tmax delay had a sensitivity of 100% (CI 95 , 94.9%–100%) and specificity of 87.8% (CI 95 , 83.6%–91.3%) for presence of a DMVO, yielding an area under the receiver-operating characteristic curves of 0.939 (CI 95 , 0.920–0.957). All 4 readers achieved sensitivity >95% and specificity >84% for detecting DMVOs using Tmax maps, with diagnostic accuracy (area under the receiver-operating characteristic curves) and speed that were significantly ( P <0.001) higher than on CTA. Conclusions: Territorial Tmax delay had perfect sensitivity and high specificity for a DMVO. Tmax maps were accurately and rapidly interpreted by even inexperienced readers, and causes of false positives are easy to recognize and dismiss. These findings encourage the use of Tmax to identify patients with DMVOs.
Recent studies concerning parental attitudes toward preschool mainstreaming indicate a favorable disposition toward this arrangement by parents of typical children and those of children with disabilities in mainstreamed settings. This study seeks to replicate and extend these findings. Discussed are the first-year results of a 5-year longitudinal study of parental attitudes toward mainstreaming in school-age programs. Surveyed were 230 parents. Results indicated that the parents, regardless of their child's preschool placement in a mainstreamed or segregated program, held very favorable opinions toward mainstreaming. However, the parents of typical children and the parents of children with disabilities in the mainstream settings indicated greater satisfaction with their child's involvement in a mixed grouping of children, and stronger opinion that this involvement influenced their child's development, than did their counterparts in the segregated settings. Correlations of these results with length of time in preschool and level of child functioning are also discussed.
The CFA Institute Research Foundation is a notfor-profit organization established to promote the development and dissemination of relevant research for investment practitioners worldwide. Neither the Research Foundation, CFA Institute, nor the publication's editorial staff is responsible for facts and opinions presented in this publication. This publication reflects the views of the author(s) and does not represent the official views of the CFA Institute Research Foundation.
Coronary artery aneurysms are rare. We present an unusual case of an isolated coronary artery aneurysm in the obtuse marginal artery detected on a computed tomographic coronary angiogram, which is unlikely to be significant for the patient. A Medline literature search did not find a similar case.
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