Proximal humerus fractures are becoming more common due to the aging of the population, and more related scientific research is also emerging. Biomechanical studies attempt to optimize treatments, taking into consideration the factors involved, to obtain the best possible treatment scenario. To achieve this, the use of finite element analysis (FEA) is necessary, to experiment with situations that are difficult to replicate, and which are sometimes unethical. Furthermore, low costs and time requirements make FEA the perfect choice for biomechanical studies. Part of the complete process of an FEA involves three-dimensional (3D) bone modeling, mechanical properties assignment, and meshing the bone model to be analyzed. Due to the lack of standardization for bone modeling, properties assignment, and the meshing processes, this article aims to review the most widely used techniques to model the proximal humerus bone, according to its anatomy, for FEA. This study also seeks to understand the knowledge and bias behind mechanical properties assignment for bone, and the similarities/differences in mesh properties used in previous FEA studies of the proximal humerus. The best ways to achieve these processes, according to the evidence, will be analyzed and discussed, seeking to obtain the most accurate results for FEA simulations.

Proximal humerus fractures increase with the aging of the population. Due to the high failure rates of surgical treatments such as open reduction and internal fixation (ORIF), biomechanical studies seek to optimize the treatments and intervening factors to improve the quality of life of people undergoing these treatments. The aim of the present study was to determine the optimal insertion angle configuration of screws used in a two-part proximal humerus fracture-locking plate osteosynthesis treatment based on finite element analysis (FEA). A series of 3D models of PHILOS locking plates with different screw insertion angle configurations were designed using a matrix system for screw angulation. The locking plate models were evaluated in a two-part proximal humerus fracture with surgical neck fracture under bending and compressive loading conditions using FEA and statistically analyzed using a design of experiments (DOE). The optimal screw insertion angle setting showed an improvement in relation to the interfragmentary strain value of the fracture. Moreover, calcar screws were the most significant feature in fracture stability throughout the tests, followed by the divergence of the most proximal screws and the proximal–distal alignment of the locking plate.