The medical term for elevated blood pressure is hypertension (HTN). It's harmful since it strains the heart and increases the risk of heart disease and stroke as well as atherosclerosis (hardening of the arteries). Congestive heart failure, renal damage, and blindness are all possible outcomes of HTN. Many adverse effects are commonly associated with traditional antihypertensives. For the most part, people in underdeveloped nations prefer herbal medicines for primary health care since they are more tolerable by the human body and have less adverse effects. A great deal of effort has been made over the last three decades to discover native plants that have hypotensive and antihypertensive medicinal properties. It has been established that some of these medicinal herbs have hypotensive and antihypertensive properties, whereas others have been discredited. In order to evaluate the efficacy and clarify the safety profile of such herbal treatments for their antihypertensive potential, additional scientific study must be conducted to combine ayurveda expertise with modern medicine.
The immune system has the ability to provoke inflammation in response to a wide variety of different triggers. Toxic chemicals, infectious diseases, radiation, and cells that have been harmed are some examples of these stimuli. It removes the detrimental stimuli and at the same time initiates the healing process, which is a win-win situation. As a result, the protective reaction of inflammation is essential for ensuring that the body continues to function properly. The majority of the time, cellular and molecular activities and interactions work together to successfully minimise the risk of experiencing damage or infection during acute inflammatory reactions. This is because these activities and interactions are coordinated to function together. This review article was prepared utilising materials written in English, and it has been published in time intervals of 15 years beginning in 1995 and continuing all the way up until the current day. Both systematic reviews and randomised controlled trials (RCTs), which are considered to be the two most reliable types of research, were included in the collection of publications that were pertinent to the goal that we set for ourselves. The first two approaches are the only ones that should be prioritised above the others. Studies with an open label and studies with cohorts are not as essential as those with a case-control design, which are called preclinical trials.
Rheumatoid arthritis (RA) is an autoimmune disease that affects the joints. Age, gender, genetics, and environmental exposure are all factors (cigarette smoking, air pollutants, and occupational). If untreated, felty syndrome, rheumatoid vasculitis, and irreversible joint damage might occur, necessitating splenectomy. Because there is no cure for RA, treatment seeks to reduce pain and prevent further damage. To develop effective RA treatments, researchers must first understand how the disease advances in people and how pathogenic pathways influence this progression. Modern pharmacologic therapy have made tremendous progress in obtaining illness remission without joint deformity (including conventional and biological treatments as well as novel potential small-molecule disease-modifying drugs). Despite this, many RA patients do not respond well to conventional treatments, necessitating the development of novel drugs. This comprehensive review of current advancements covers RA causation, disease-modifying drugs, and prospective RA therapeutics. This section summarises the various RA-related therapies available in the past and now.
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