Syphilis in pregnancy is a worrisome topic due to its fetal consequences. The diagnosis and management of such a case might be intriguing when overlapped with Behçet’s disease, an inflammatory disease involving multiple organ systems. This case presents a 35-year-old pregnant female, a known case of Behçet’s disease and hypothyroidism, presenting at 33 weeks to the emergency department at Bahrain Defense Force (BDF) hospital with vaginal leaking and a solitary oral ulcer. As per the guidelines of the ministry of health, she underwent perinatal screening and was found to be positive for the venereal disease research laboratory (VDRL) test and was diagnosed with latent syphilis. The diagnosis of latent syphilis in a known case of Behçet’s disease presenting with a solitary oral ulcer is unpredictable. The importance of perinatal screening is emphasized in this case report.
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