E-Health systems need to dynamically integrate a huge variety of medical sensors in order to provide a meaningful survey of a patient's condition. Devices like smart phones or gateways usually used as integrators, often underlie resource constraints and have to cope with the mobility of the patient. Therefore it is difficult to realize an overall integration middleware, that allows to handle a sufficient amount of medical sensors and is able to quickly adapt to changing requirements (e.g. new sensors or data aggregation modules) while preserving mobility and resource constraints. We present a middleware solution for the integration of medical devices and the aggregation of resulting data streams, that is able to adapt itself to the requirements of patients and Care Delivery Operators, using a modular approach and external knowledge repositories. Knowledge in the shape of configurations and runtime pluggable software modules is used to properly integrate and handle discovered medical devices on demand.
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