Improving vitamin D status through dietary supplementation is unlikely to reduce CVD risk factors. Confounding of seasonality should be recognized and addressed in future studies of vitamin D.

Settlements variously termed ‘ex-urbs’, ‘edge cities’, ‘technoburbs’ are taken to signal something different from suburbia and as a consequence might be considered post-suburban. Existing literature has focused on defining post-suburbia as a new era and as a new form of settlement space. Whether post-suburbia can also be delimited in terms of its distinctive politics is the open question explored here. The paper begins by considering the need to make urban political theory more tailored to the different settlements that populate the heavily urbanised regions of nations. The paper stresses the structural properties of capitalism that generate differences within the unity of the urbanisation process. It then discusses what is new about a class of post-suburban settlements, concentrating on what the increasing economic gravity of post-suburbia, the difficulty of bounding post-suburban communities and the continuing role of the state imply for understanding urban politics and the reformulation of urban political theory.

Stroke-associated pneumonia is not associated with increased long-term mortality, but it is linked with increased mortality up to 1 year, prolonged LOS, and poor functional outcome on discharge. Targeted intervention strategies are required to improve outcomes of SAP patients who survive to hospital discharge.

The emergence over the last 30^40 years of what is variously termed edge city, edgeless, and postsuburban development in North America and elsewhere raises a set of challenges for urban theory and existing ways of understanding the politics of urban growth and management. These challenges and their global import have been outlined in their broadest terms by members of à Los Angeles School'. In this paper we try to develop the detail of some of these challenges in ways that might allow for comparative analysis. We begin by considering three analytical dimensions along which distinctively postsuburban settlements might be identified. These dimensions are not without their limitations but we regard them as a heuristic device around which to centre ongoing comparative research. We then go on to highlight three political contradictions attending postsuburban growth which appear to flow from some of these defining dimensions. To the extent that such postsuburban growth and politics are distinctive, they pose important challenges to established theories of urban politics. We briefly consider these challenges in the conclusion of the paper.

Few year-long vitamin D supplementation trials exist that match seasonal changes. The aim of this study was to determine whether daily oral vitamin D 3 at 400 IU or 1000 IU compared with placebo affects annual bone mineral density (BMD) change in postmenopausal women in a 1-year double-blind placebo controlled trial in Scotland. White women aged 60 to 70 years (n ¼ 305) were randomized to one of two doses of vitamin D or placebo. Mean BMD loss at the hip was significantly less for the 1000 IU vitamin D group (0.05% AE 1.46%) compared with the 400 IU vitamin D or placebo groups (0.57% AE 1.33% and 0.60% AE 1.67%, respectively) (p < 0.05). Mean (AE SD) baseline 25(OH)D was 33.8 AE 14.6 nmol/L; comparative 25(OH) D change for the placebo, 400 IU, and 1000 IU vitamin D groups was À4.1 AE 11.5 nmol/L, þ31.6 AE 19.8 nmol/L, and þ42.6 AE 18.9 nmol/L, respectively. Treatment did not change markers of bone metabolism, except for a small reduction in PTH and an increase in serum calcium (latter with 1000 IU dose only). The discordance between the incremental increase in 25(OH)D between the 400 IU and 1000 IU vitamin D and effect on BMD suggests that 25(OH)D may not accurately reflect clinical outcome, nor how much vitamin D is being stored.

Several studies suggest that natural salicylates in plant-based foods may benefit health. However, large variation in published values of the salicylate content of foods means that relating dietary intakes to disease risk is problematical. Consequently, we have systematically reviewed the available literature using prescribed selection criteria. By combining these literature values with in-house analysis, we have constructed a food composition database describing median salicylate values for 27 different types of fruits, 21 vegetables, 28 herbs, spices and condiments, 2 soups and 11 beverages. Application of a validated food frequency questionnaire estimated median dietary intakes of 4.42 (range 2.90-6.27) and 3.16 (2.35-4.89) mg/day for Scottish males and females, respectively. Major dietary sources of salicylates were alcoholic beverages (22%), herbs and spices (17%), fruits (16%), non-alcoholic beverages including fruit juices (13%), tomato-based sauces (12%) and vegetables (9%). Application of the database to populations with differing dietary habits and disease risk profiles may provide further evidence for the role of dietary salicylates in the prevention of chronic diseases.

We found no evidence of an improvement in physical function following vitamin D3 supplementation for 1 year.

Most trials of vitamin D supplementation have shown no benefits on bone mineral density (BMD), although severe vitamin D deficiency causes osteomalacia, which is associated with profound BMD deficits. Recently, the ViDA-BMD study from New Zealand demonstrated a threshold of baseline 25-hydroxyvitamin D (25OHD; 30 nmol/L) below which vitamin D supplementation did benefit BMD. We have now reexamined data from a similar trial in Aberdeen to determine whether a baseline 25OHD threshold of 30 nmol/L is also observed in that database. The Aberdeen study recruited 305 postmenopausal women in late winter and randomized them to receive placebo, vitamin D 400 IU/d, or vitamin D 1000 IU/d over 1 year. As previously reported, BMD loss at the hip was reduced by vitamin D 1000 IU/d only, and there was no significant treatment effect of either dose at the lumbar spine. In the present analysis, when the trial participants were grouped according to whether their baseline 25OHD was ≤30 nmol/L or above this threshold, significant treatment effects were apparent at both the spine and hip in those with baseline 25OHD ≤30 nmol/L, but no significant effects were apparent in those with baseline 25OHD above this level. There was evidence of a similar threshold for effects on parathyroid hormone, but no groups showed changes in bone turnover markers during the study. It is concluded that vitamin D supplements only increase bone density in adults with nadir 25OHD ≤30 nmol/L. This moves us further toward a trial-based definition of vitamin D deficiency in adults with adequate calcium intakes and suggests that supplement use should be targeted accordingly. Future trials of vitamin D supplementation should focus on individuals with 25OHD concentrations in this range. © 2018 American Society for Bone and Mineral Research.