The objective of the current study was to evaluate the mechanism of absorption and metabolism of a PEGylated peptide, MRL-1 (46 kDa), after s.c. dosing in dogs and rats. Thoracic lymph ductcannulated (LDC) dog and rat models were developed that allowed continuous collection of lymph for up to 8 days. When [ 3 H]MRL-1 was administered s.c. to LDC dogs, ∼73% of the administered radioactivity was recovered in pooled lymph over a period of 120 hours, suggesting that lymphatic uptake is the major pathway of s.c. absorption for this peptide. In agreement with these data, the systemic exposure of radioactivity related to [
Modern robotics is a field that integrates mechanical, electrical, computer and information systems. However, students of Engineering Technology, especially Mechanical Engineering Technology (MET), are facing two dilemmas when taking robotics courses because technology programs mainly focus on hands-on skills and there are fewer fundamental robotics-related courses in the MET curriculum than in electrical engineering technology.In order to improve the performance of the student in robotics program of MET, an educational framework based on using a wireless sensor and control network (WSCN) was devised and employed in the senior-level robotics course "Sensor and Actuator Applications in Robotics". This framework has two advantages over the former teaching methodology. First, it is low cost and used to facilitate conceptual education with popular and affordable mechatronics devices (Arduino development kit, sensors, wireless communication modules, actuators, etc.). Second, the devised ready-to-use framework avoids exposing the students to complicated algorithms and appropriately balances the students' time between theory and practice, thus letting them focus more on the applications of robotics. Therefore, both the students and instructors can take advantage of the limited number of class hours to develop sophisticated projects. During the implementation, the course was redesigned based on pre-class survey results and the assessment of the students' abilities. Subsequently, the students were instructed to familiarize themselves with basic sensors and actuators, the Arduino development kit and c-based programming with Arduino Integrated Development Environment (IDE). Then, the framework was implemented into the course. Over the course of the semester, a series of homework and projects were assigned. Through these assignments, the students were able to build practical devices within the framework. This framework enhanced the students' understanding of the fundamental concepts, and the practical applications inspired the students' interest in this course, which also improved their performance.
One of the problems that many engineering graduates face when looking for their first job is: do you have experience? Employers prefer graduates with relevant experience to those without. Why is experience so important to employers? Can students accumulate “working” experience while studying in college? This paper discusses the use of design projects inside and outside of classrooms to help students gain “working” experience and skills through hands-on design activities that simulate the actual design activities that occur in the industry. Faculty members from the Mechanical Engineering Technology and Computer Engineering Technology departments were involved in creating multidisciplinary design projects. The design projects give students new insights into what they learn in their coursework and provide students the valuable experiences in analytical skills, concurrent engineering approach, people skills, and management skills needed for the students when looking for employment.
earned his master's in mechanical engineering from the City College of New York in 1987 and his Ph.D. in mechanical engineering from the Graduate Center of the City University of New York in 1995. Prior joining the Mechanical Engineering Technology department at City Tech, he served as an engineering instructor for the JUMP, an engineering training program sponsored by the New York State Department of Transportation. Professor Zhangs research area includes materials testing, composite materials, CAD/CAE, mechatronics, and engineering animation.
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