Asymptotic safety describes a scenario in which general relativity can be quantized as a conventional field theory, despite being nonrenormalizable when expanding it around a fixed background geometry. It is formulated in the framework of the Wilsonian renormalization group and relies crucially on the existence of an ultraviolet fixed point, for which evidence has been found using renormalization group equations in the continuum."Causal Dynamical Triangulations" (CDT) is a concrete research program to obtain a nonperturbative quantum field theory of gravity via a lattice regularization, and represented as a sum over spacetime histories. In the Wilsonian spirit one can use this formulation to try to locate fixed points of the lattice theory and thereby provide independent, nonperturbative evidence for the existence of a UV fixed point.We describe the formalism of CDT, its phase diagram, possible fixed points and the "quantum geometries" which emerge in the different phases. We also argue that the formalism may be able to describe a more general class of Hořava-Lifshitz gravitational models.

The dynamical generation of a four-dimensional classical universe from nothing but fundamental quantum excitations at the Planck scale is a long-standing challenge to theoretical physicists. A candidate theory of quantum gravity which achieves this goal without invoking exotic ingredients or excessive fine-tuning is based on the nonperturbative and background-independent technique of Causal Dynamical Triangulations. We demonstrate in detail how in this approach a macroscopic de Sitter universe, accompanied by small quantum fluctuations, emerges from the full gravitational path integral, and how the effective action determining its dynamics can be reconstructed uniquely from Monte Carlo data. We also provide evidence that it may be possible to penetrate to the sub-Planckian regime, where the Planck length is large compared to the lattice spacing of the underlying regularization of geometry.

We show that the quantum universe emerging from a nonperturbative, Lorentzian sum over geometries can be described with a high accuracy by a four-dimensional de Sitter spacetime. By a scaling analysis involving Newton's constant, we establish that the linear size of the quantum universes under study is in between 17 and 28 Planck lengths. Somewhat surprisingly, the measured quantum fluctuations around the de Sitter universe in this regime are to good approximation still describable semiclassically. The numerical evidence presented comes from a regularization of quantum gravity in terms of causal dynamical triangulations.

The theory of causal dynamical triangulations (CDT) attempts to define a nonperturbative theory of quantum gravity as a sum over space-time geometries. One of the ingredients of the CDT framework is a global time foliation, which also plays a central role in the quantum gravity theory recently formulated by Hořava. We show that the phase diagram of CDT bears a striking resemblance with the generic Lifshitz phase diagram appealed to by Hořava. We argue that CDT might provide a unifying nonperturbative framework for anisotropic as well as isotropic theories of quantum gravity.

Using random matrix technique we determine an exact relation between the eigenvalue spectrum of the covariance matrix and of its estimator. This relation can be used in practice to compute eigenvalue invariants of the covariance (correlation) matrix. Results can be applied in various problems where one experimentally estimates correlations in a system with many degrees of freedom, like for instance those in statistical physics, lattice measurements of field theory, genetics, quantitative finance and other applications of multivariate statistics.

Previous work has shown that the macroscopic structure of the theory of quantum gravity defined by causal dynamical triangulations (CDT) is compatible with that of a de Sitter universe. After emphasizing the strictly nonperturbative nature of this semiclassical limit we present a detailed study of the three-volume data, which allows us to re-confirm the de Sitter structure, exhibit short-distance discretization effects, and make a first detailed investigation of the presence of higher-order curvature terms in the effective action for the scale factor. Technically, we make use of a novel way of fixing the total four-volume in the simulations.

We perform a first investigation of the coupling constant flow of the nonperturbative lattice model of four-dimensional quantum gravity given in terms of Causal Dynamical Triangulations (CDT). After explaining how standard concepts of lattice field theory can be adapted to the case of this background-independent theory, we define a notion of "lines of constant physics" in coupling constant space in terms of certain semiclassical properties of the dynamically generated quantum universe. Determining flow lines with the help of Monte Carlo simulations, we find that the second-order phase transition line present in this theory can be interpreted as a UV phase transition line if we allow for an anisotropic scaling of space and time.

In the fly's visual system, the morphology of cells and the number of synapses change during the day. In the present study we show that in the first optic neuropil (lamina) of Drosophila melanogaster, a presynaptic active zone protein Bruchpilot (BRP) exhibits a circadian rhythm in abundance. In day/night (or light/dark, LD) conditions the level of BRP increases two times, in the morning and in the evening. The same pattern of changes in the BRP level was detected in whole brain homogenates, thus indicating that the majority of synapses in the brain peaks twice during the day. However, these two peaks in BRP abundance, measured as the fluorescence intensity of immunolabeling, seem to be regulated differently. The peak in the morning is predominantly regulated by light and involves the transduction pathway in the retina photoreceptors. This peak is present neither in wild-type Canton-S flies in constant darkness (DD), nor in norpA(7) phototransduction mutant in LD. However, it also depends on the clock gene per, because it is abolished in the per(0) arrhythmic mutant. In turn, the peak of BRP in the evening is endogenously regulated by an input from the pacemaker located in the brain. This peak is present in Canton-S flies in DD, as well as in the norpA(7) mutant in LD, but is absent in per(01), tim,(01) and cry(01) mutants in LD. In addition both peaks seem to depend on clock gene-expressing photoreceptors and glial cells of the visual system.