With the stable low heart rate at the minimal physiological values the bleeding in the operative field depends on MAP. Keeping HR around 60 b/min there is no need to decrease the MAP to dangerously low levels to achieve good operative field conditions in great proportion of patients.
During transnasal endoscopic procedures performed in moderate hypotension, in addition to significant drop of blood flow velocity to values well below the normal reference range, a divergent reduction of systolic and diastolic velocity was detected. Since divergent systolic and diastolic velocity may indicate an early phase of cerebral autoregulation compromise, and the decrease of mean blood flow velocity in MCA corresponds with a decrease of cerebral blood flow, further investigations in this field seem warranted.
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