A alopecia androgenética se caracteriza pela perda progressiva dos cabelos. Para o tratamento tópico dessa condição, a via folicular é considerada a mais rápida na disponibilização dos ativos. Recentemente, alguns estudos mostraram que a cafeína possui efeitos benéficos em pacientes acometidos por esta condição. O objetivo foi realizar um estudo de pré-formulação de shampoo contendo cafeína para tratamento da alopecia androgenética. Foi realizada a manipulação da base em shampoo para a veiculação do ativo cafeína, e sua estabilidade foi analisada através de parâmetros físico-químicos pré-determinados. As amostras foram mantidas nas temperaturas 5 ± 2ºC, 40 ± 2ºC e 20 ± 2ºC por 15 dias. A formulação apresentou boa aparência e homogeneidade nos tempos T0, T7 e T15, viscosidade de 11386 mPa.s, pH 6,28 e densidade 1,024 g/mL, mantendo-se estável até a última análise, sendo a formulação proposta viável ao universo magistral.Palavras-chave: Alopecia; Cafeína; Estabilidade de cosméticos. ABSTRACTAndrogenetic alopecia is characterized by progressive loss of hair. For topical treatment, the follicular route is considered the fastest for the availability of the assets. Recently, some studies have shown that caffeine has beneficial effects in patients with this condition. The objective was to carry out a preformulation study of caffeine-containing shampoo for the treatment of androgenetic alopecia.The manipulation of the base in shampoo was performed for the placement of caffeine, and its stability was analyzed through pre-determined physical-chemical parameters. The samples were maintained at temperatures 5 ± 2° C, 40 ± 2° C and 20 ± 2° C for 15 days. The formulation presented good appearance and homogeneity at times T0, T7 and T15, viscosity of 11386 mPa.s, pH 6.28 and density 1,024 g / mL, remaining stable until the last analysis, being the proposed formulation viable to the masterful universe.
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