Analysis of COVID-19 features in individuals who regularly practice aerobic training. Methods. Asymptomatic persons and patients with COVID-19 older than 30 years, 293 people (180 men and 113 women), 214 of them – inhabitants of the Moscow region (the beginning of the sampling – 2nd decade of April 2020) and 79 – inhabitants of the Belgorod region (the beginning of the sampling – 2nd decade of May 2020), adapted (27 people 1st group) and unadapted (266 – control group) to aerobic training (AT). Computer tomography of the chest, RNA test for SARS-CoV-2 in smears from the nasopharynx-oropharynx, the clinical blood sample and level of antibodies to SARS-CoV-2 were studied. The criterion for adaptation to aerobic loads was considered compliance with the rules of the American Heart Association, 2008. Results. Adapted to AT individuals, in contrast to the control group, characterized with the prevalence of asymptomatic (p = 0.045) and absence of severe forms of COVID-19, limited cataral simptoms of the disease (p < 0.001), rare pneumonia with absence (1) or presence (2) of acute respiratory failure (p1 = 0,028; p2 = 0,034), along with lower prevalence of diseases, potentiating this infection (p = 0.03). Conclusion. Patients adapted to AT have less severe course of COVID-19.
The analysis of the mechanisms of the formation of a rare clinical combination of pulmonary embolism (PE) and diffuse alveolar hemorrhage (DAH), which are complications of systemic vasculitis associated with antibodies to the cytoplasm of neutrophils (primarily granulomatosis with polyangiitis), systemic lupus erythematosus and secondary antiphlogistic syndrome primary antiphospholipid syndrome and Goodpastures syndrome. Taking into account the chronological sequence of the occurrence of PE and DAH, 3 variants of the onset of these potentially fatal additions to the underlying disease were considered: the anticipatory DAH development of PE, delayed from DAH PE and joint (within 24 hours) formation of PE and DAH. A review of single descriptions of such a combination of complications of granulomatosis with polyangiitis is carried out, criteria are indicated, a working classification of severity is given and, taking this into account, a modern program of therapy for DAH as an independent event and in combination with PE.
A rare observation of systemic AL-amyloidosis with a debut in old age, accompanied by diffuse alveolar-septal lesion of the lungs and mediastinal lymphadenopathy in combination with amyloid cardiomyopathy in the absence of pathology of kidney and liver function.
Introduction. Fountains (office and outdoor), being small decorative structures used to improve the parameters of the human life environment, in the process of their work during the generation of a water jet, determine the creation of spray and aerosol fractions, thereby allowing the loss of a certain volume of liquid when air moves and wind carryover. The biological safety of the operation of such hydraulic structures depends on the composition of the microflora of the water in the main reservoir of the fountain, especially in the warm season. Materials and methods. For the period 2010-2020, the study of the composition of the microflora of water in the main reservoirs of the existing fountains and in the sedimented spray-aerosol mixture formed during the operation of these hydraulic structures was carried out. Results. At water temperatures above +18 °C and the absence of a disinfection system or its regular complete replacement, fountains were found to have a significant level of contamination with bacterial and fungal pathogens, including mycobacterium tuberculosis; the number of microorganisms of the E. coli group in office and open city fountains. The amount of Clostridial flora and streptococci in open fountains significantly exceeds the standard indicators (p <0.05). Limitations. When studying the trends in concentration of liquid particles in the air, the methodology of K.Y. Kondratiev et al. (1988) and V.M. Khvata et al. (1991) was used. The studies were carried out in accordance with the Interstate standard “Water. Methods of sanitary and bacteriological analysis for field conditions” GOST 24849-2014, 2016. Conclusion. The microflora of the operating fountain, in the absence of disinfection of water or its regular replacement, is characterized by a high titer of bacteria of the E. coli group, streptococci, staphylococci, mycobacterium tuberculosis, mold and yeast fungi. The one of the conditions for the excessive growth of these microorganisms in this hydraulic system is the water temperature above 18 °C. In the sedimented aerosol near the active fountain, a bacterial and fungal spectrum of pathogenic microorganisms similar to the water is found. Fountains (external and office) can be considered as sources of aerogenic household infection of the population of modern cities, which requires strict adherence to sanitary norms and rules that ensure the biological safety of these hydraulic structures.
Федеральное государственное автономное образовательное учреждение высшего образования «Белгородский государственный национальный исследовательский университет» Министерства образования и науки Российской Федерации: 308015, Белгород, ул. Победы, 85; 2-Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов»: 117198, Москва, ул. Миклухо-Маклая, 6 Информация об авторах Третьяков Андрей Юрьевич-д. м. н., профессор Медицинского института Федерального государственного автономного образовательного учреждения высшего образования «Белгородский государственный национальный исследовательский университет» Министерства образования и науки Российской Федерации; тел.:
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