Despite all the efforts of medical services, the socio-economic damage caused by chronic heart failure (CHF) is increasing. Approximately 10-40% of patients with CHF also suffer from chronic obstructive pulmonary disease (COPD). The comorbid course of these pathologies aggravates the prognosis of patients. Moderate physical activity is recommended as a non-drug therapy for both pathologies. The aim of the study: was to evaluate the effectiveness of physical rehabilitation in patients with chronic heart failure and chronic obstructive pulmonary disease by determining the levels of NT-proBNP, high-sensitivity C-reactive protein, IL-1β, IL-6, TNF-α. Methods: The study included 240 patients with CHF. After the initial examination, the patients were divided into groups depending on the presence or absence of COPD and the value of LVEF. Subsequently, each group was divided into a subgroup that took part in physical rehabilitation in addition to standard medical therapy and another one consist of patients that received only standard therapy. A year later, the levels of NT-proBNP, high-sensitivity C-reactive protein, IL-1β, IL-6 and TNF-α were re-determined. Results and Conclusion: CHFpEF patients have higher levels of hs-CRP and pro-inflammatory cytokines compared to patients with CHFrEF. The combination of COPD and CHF enhances systemic inflammation and myocardial remodeling processes, determined by the level of NT-proBNP in comparison with the isolated course of CHF. Physical rehabilitation in patients with a comorbid course of COPD and CHF is accompanied by a significant decrease in the levels of pro-inflammatory cytokines, hs-CRP and NT-proBNP. Keywords: chronic heart failure, chronic obstructive pulmonary disease, physical rehabilitation
Nowadays, more than 485 million people in the world suffer from cardiovascular diseases (CVD). According to large epidemiological studies, the group of CVD is the leading cause of death in the world. One of the neurohumoral mechanisms that appears to be a risk factor for CVD is thyroid dysfunction. In this regard, in recent years, more and more attention is paid to the study the influence of subclinical hypothyroidism on the occurrence and development of cardiovascular disorders. MeSH words: cardiovascular diseases, subclinical hypothyroidism
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.