The ambient-pressure endstation and branchline of the Versatile Soft X-ray (VerSoX) beamline B07 at Diamond Light Source serves a very diverse user community studying heterogeneous catalysts, pharmaceuticals and biomaterials under realistic conditions, liquids and ices, and novel electronic, photonic and battery materials. The instrument facilitates studies of the near-surface chemical composition, electronic and geometric structure of a variety of samples using X-ray photoelectron spectroscopy (XPS) and near-edge X-ray absorption fine-structure (NEXAFS) spectroscopy in the photon energy range from 170 eV to 2800 eV. The beamline provides a resolving power hν/Δ(hν) > 5000 at a photon flux > 1010 photons s−1 over most of its energy range. By operating the optical elements in a low-pressure oxygen atmosphere, carbon contamination can be almost completely eliminated, which makes the beamline particularly suitable for carbon K-edge NEXAFS. The endstation can be operated at pressures up to 100 mbar, whereby XPS can be routinely performed up to 30 mbar. A selection of typical data demonstrates the capability of the instrument to analyse details of the surface composition of solid samples under ambient-pressure conditions using XPS and NEXAFS. In addition, it offers a convenient way of analysing the gas phase through X-ray absorption spectroscopy. Short XPS spectra can be measured at a time scale of tens of seconds. The shortest data acquisition times for NEXAFS are around 0.5 s per data point.
The backscatter response of a seabed to an incident sonar signal is dependent on the carrier wave frequency: i.e., the seabed is acoustically colourful. Colour is implemented in a prototype three-frequency sidescan sonar system deployed in the Pentland Firth, north Scotland. Sonar amplitude data as a function of frequency are processed to render them an unconfounded effect of the seabed normalized to the response at a reference inclination angle, for colour to be a meaningful property of the seabed. Methods for mapping data at sonar frequencies to optical primary colours for human visualisation are explored. We recommend methods that in our opinion generate colour characteristics harmonious with human vision in which: shadow is white; saturation black; colour shade darkness is proportional to backscatter strength; and shades of red, green and blue are seen in proportion to the backscatter amplitudes of the low-, mid-and high-frequency sonar data. Frequency equalisation is applied to achieve a balance in colour responses in images. The seabed in the survey area is acoustically colourful. Using the "negative BGR" colour mapping method: a weakly backscattering sand dune in the north of the survey area appears as shades of light blue and purple; a strongly backscattering halo of cobbles around the dune appears as shades of hazel brown; a strongly backscattering gravel ridge across the south of the survey area appears as shades of royal blue; and exposed rock as textures ranging in colour from light brown to light blue/green. There is evidence for colour anisotropy (a dependence of colour on the direction of ensonification). Similarities between anthropic colour sonar and the natural sonar of Microchiropteran bats are noted. Bats' sonar satisfies the information criteria for acoustic colour, and it is hypothesized that it informs a colourfully-perceived world view.
This paper discusses the importance of fusion propulsion for interplanetary space travel, illustrates why the magnetoinertial fusion parameter space may facilitate the most rapid, economic path for development, justifies the choice of pulsed Z pinch, and provides a potential development path leading up to a technical readiness level 9 system. Round trips of less than one year to Mars are only possible using fusion propulsion systems. Such a system will require an onboard nuclear fission reactor for reliable startups, and so fission and fusion developments for space are mutually beneficial. The paper reviews the more than 50 year history of fusion research and summarizes results from a recent study of the fusion parameter space for terrestrial power, which suggests magnetoinertial fusion can provide the smallest, most economical approach for a fusion propulsion system. Emerging experimental data and theory show pulsed Z-pinch fusion solves some of the most deleterious instabilities and scales to fusion breakeven within reach of current pulsed power facilities. The paper illustrates a potential development path to a technical readiness level 9 flight system, starting from an assumed technical readiness level 2 for the current state of fusion propulsion. Nomenclature a = acceleration, m∕s 2 g 0 = gravitational acceleration at Earth's surface, m∕s 2 J = mission difficulty parameter, m 2 ∕s 3 k = ratio of tank to propellant mass m = mass, kg _ m = mass flow rate, kg∕s N = total number of stages, number of fusion reactions n = number density P = power, W R = distance traveled, m T = total trip time and time, s t = time, s V = reacting volume, m 3 v j = jet or exhaust velocity, m∕s Y = fusion energy yield, J α = propulsion system specific mass, kg∕W β = mission type multiplication factor γ = ratio of propulsion system to initial mass of nth stage Δv = velocity increment, m∕s λ = payload mass fraction τ = characteristic time, s Subscripts burn = propulsive burn c, coast = unpowered coasting conf = confinement d = dwell, as in dwell time τ d f = final fus = fusion jet = jet, as in for jet power P jet n = number of the stage opt = optimum p = propulsion time pay = payload pn = propulsion time for nth stage (as in for T pn ) pr = propellant ps = propulsion system t = tank 0 = initial 1, 2 = dummy subscripts indicating different species
Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretory phenotype are vast, yet ill characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and their detection a priority. The Cellular Senescence Network (SenNet), a National Institutes of Health Common Fund initiative, was established to address this need. The goal of SenNet is to map SnCs across the human lifespan to advance diagnostic and therapeutic approaches to improve human health. State-of-the-art methods will be applied to identify, define and map SnCs in 18 human tissues. A common coordinate framework will integrate data to create four-dimensional SnC atlases. Other key SenNet deliverables include innovative tools and technologies to detect SnCs, new SnC biomarkers and extensive public multi-omics datasets. This Perspective lays out the impetus, goals, approaches and products of SenNet.
Novel in situ synchrotron total scattering measurements probe the assembly of primary building units into templated hierarchically porous aluminophosphate catalysts, providing unique insights to understanding crystallisation kinetics.
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