1. The results of the administration of the nonapeptide inhibitor (SQ 20,881) of the enzymatic conversion of angiotensin 1 into angiotensin I1 in twelve severe hypertensive patients are presented.2. Administration of the compound was associated with a fall in blood pressure in ten of twelve patients.3. Four patients had a normal plasma renin activity (PRA) with a range of 1.6-3.7 ng h -' ml-' and eight patients had a high PRA with a range of 5.0-74 ng h -' m1-l. Two of the patients with normal PRA had no fall in blood pressure despite receiving 2 mg/kg of the compound. Two patients with normal PRA, however, did respond, thus indicating that a high PRA is not necessary for a response to the inhibitor compound, 4. It was found that haemodialysis or diuresis with frusemide enhanced the blood pressure response to the compound. 5. The presence of a measured low total blood volume was found to be associated with an exaggerated fall in blood pressure to a small dose of compound (0.125 mg/kg) in one patient.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.