The analysis of MR images is evolving from qualitative to quantitative. More and more, the question asked by clinicians is how much and where, rather than a simple statement on the presence or absence of abnormalities. The authors present a study in which the results obtained with a semiautomatic, multispectral segmentation technique are quantitatively compared to manually delineated regions. The core of the semiautomatic image analysis system is a supervised artificial neural network classifier augmented with dedicated preand postprocessing algorithms, including anisotropic noise filtering and a surface-fitting method for the correction of spatial intensity variations. The study was focused on the quantitation of white matter lesions in the human brain. A total of 36 images from six brain volumes was analyzed twice by each of two operators, under supervision of a neuroradiologist. Both the intra- and interrater variability of the methods were studied in terms of the average tissue area detected per slice, the correlation coefficients between area measurements, and a measure of similarity derived from the kappa statistic. The results indicate that, compared to a manual method, the use of the semiautomatic technique not only facilitates the analysis of the images, but also has similar or lower intra- and interrater variabilities.

In heavily over-consolidated clays there is a marked peak in the observed relation between shear stress and shear strain. As the strain increases, the stress falls from a peak to a much smaller residual stress. Slopes made from such a clay often fail progressively many years after construction. Sliding occurs on a concentrated slip surface, and it is found that the mean resolved shear stress on that surface is markedly less than the peak shear strength. Concepts from fracture mechanics, and in particular the J -integral, are used to derive conditions for the propagation of a concentrated shear band of this kind. The results indicate the presence of a strong size effect, which has important implications for the use of models in soil mechanics. An elastic analysis makes it possible to determine the size of the end zone in which the shear stress on the shear band falls to its residual value. An attempt is made to assess the possible sources of the time-dependence governing propagation speed of the shear band. They include pore-water diffusion to the dilating tip of the band (which governs the rate at which local strength reductions can occur), viscoelastic deformation of the clay (which allows a gradual build-up of strain concentration at the tip of the band), and the weathering break-down of diagenetic bonds.

Experiments at 8.0 MPa and 277.15 K were carried out in different porous media, such as silica sand and activated carbon, to observe the formation and dissociation of methane hydrate in a specially designed crystallizer for mophology observation. In silica sand bed, we observed a clear hydrate front moving across the bed in the crystallizer at the experimental conditions with 50 and 100% water saturation. The hydrate crystals were observed to form in the interstitial pore space available between the silica sand particles. Whereas in activated carbon bed experiments, hydrates were observed to nucleate on the surface of the activated carbon grain and then dissociate within the stable hydrate formation region. For the first time, we were able to observe this behavior of transient hydrate crystal formation/dissociation in the stable hydrate region in porous media. We postulated that the particle size, pore space, and water saturation level may play a role in the above phenomenon. A clear hydrate front movement across the crystallizer and stable hydrate formation were observed when smaller sized activated carbon grains were used. In all of the experiments, the hydrate crystals were seen to form in the interstitial pore space between the porous media. Our results show that pore space and its interconnectivity play an important role in methane hydrate formation in porous media consisting of silica sand or activated carbon.

Silicon-carbon nanofibers coaxial sponge, with strong mechanical integrity and improved electronic conductivity, is a promising anode structure to apply into commercial high-capacity lithium ion batteries. We characterized the electrochemical and mechanical behaviors of amorphous silicon-coated carbon nanofibers (a-Si/CNFs) with in situ transmission electron microscopy (TEM). It was found that lithiation of the a-Si coating layer occurred from the surface and the a-Si/CNF interface concurrently, and propagated toward the center of the a-Si layer. Such a process leads to a sandwiched Li(x)Si/Si/Li(x)Si structure, indicating fast Li transport through the a-Si/CNF interface. Nanocracks and sponge-like structures developed in the a-Si layer during the lithiation-delithiation cycles. Lithiation of the a-Si layer sealed in the hollow CNF was also observed, but at a much lower speed than the counterpart of the a-Si layer coated on the CNF surface. An analytical solution of the stress field was formulated based on the continuum theory of finite deformation, explaining the experimental observation of longitudinal crack formation and general mechanical degradation mechanism in a-Si/CNF electrode.