Using tile patch-clamp method in 27 different reside-out patches it was shown for the first time that they defined tile basic parameters of tile functioning of tangle ATP-~ensitive K + channels in the human adult ventricular cardiomyocytes membrane. At [K+]o = 140 mM ~ingi~ channel conductance (over tile linear part of the 1-I-' relation) reaches 100 pS. The possibility of tile existence of the~e channels' conductance sublevels a~ well as the clunter character of their localization in sarcolemma is ~hown. The channel actiwty demonstrates an obvious run.down with v at about a minute The analy~ed channels possess one open and two clo~ed ~tates.ATP-~cnsitive K+-chaanel, Human adult ventllcular cardiom;/ocyte
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