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Myofascial pain syndrome (MPS) is a common soft tissue disorder estimated to affect more than three-fourths of the general American population at least once during their lifetime. In this day of age, depression is remarkably the leading cause of disability affecting the mind and the emotional state of health. Depression is a serious mental state affecting more than 300 million people worldwide. Depression is said to be associated with chronic myofascial pain due to its dual neuronal connection, both believed to have been influenced by serotonin and nor-epinephrine. As a result, treatment goals should not be directed on the emotional symptoms alone but emphasis should be laid on the physical symptoms as well. Primary healthcare providers should emphasize the intensity and extent of physical symptoms associated with soft tissue disorders. A depressive mood disorder is more often than not associated with physical pain, as is the case with a number of patients presenting at primary care. These patients seek treatment for physical symptoms alone, making depression even harder to diagnose. Depressive mood and physical pain are closely interlinked with each other. Medical intervention with antidepressants that act as both serotonin and norepinephrine reuptake inhibitors in correcting chemical imbalances are indicated for alleviating physical symptoms in depressed individuals.

The WHO declaration of the novel coronavirus (Covid-19) caused by SARS-CoV-2 as a pandemic has raised serious questions and has since been a global health concern. Data on the clinical characteristics, laboratory findings of deceased covid-19 individuals are sparse. The study analyzed the clinical and laboratory profiles of Covid-19 deceased in Zoram Medical College Mizoram, India. We gathered information from the Mizoram Government Covid-19 portal and hospital medical record section. The study examined eight confirmed Covid-19 deaths out of the total nine Covid-19 fatalities reported in Mizoram as of February 14, 2021. The decedents' mean age was 62.88 (±18.659) years; among them, 87.5% were males, and blood group B was associated with half of the deceased. In Mizoram, the case fatality rate, crude death rate, and recovery rate were 0.2%, 7.27 per million, and 99.40%, respectively, with 3547 cases per million. The median length of hospital and ICU stay (between admission and death) was 15.5 and 11 days. The common presenting symptoms were fever (75%), shortness of breath (62.5%), cough/ sore throat (50%). Hypertension (62.5%) and diabetes mellitus (62.5%) were the two most prevalent comorbidities, followed by cardiovascular diseases (25%). The concurrence of hypertension and diabetes mellitus constituted 87.5%, 75% of the decedents reported the presence of at least one of the comorbidities. The two most common complications were an acute respiratory failure (87.5%) and cardiovascular complications (87.5%). Increased risk of severe Covid-19 disease increases with advanced age (>60 years), gender (male), and underlying comorbidities.

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