We report the F-FDG PET/CT appearance of a metastatic biopsy-proven malignant fibroxanthoma of the ankle. A 41-year-old female patient with a history of scleroderma presented with a fungating mass in the left ankle. Shave biopsy of the overlying skin showed atypical fibroxanthoma (AFX). Staging FDG PET/CT demonstrated a hypermetabolic exophytic soft tissue mass in the left ankle with local extension to bone and widespread metastatic disease including pulmonary parenchyma, nodes, bone marrow, and skeletal muscle. While rare, knowledge of the potential aggressive nature of AFX is important for accurate diagnosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.