Resonance Raman spectroscopy has allowed the direct observation of the Fe(IV) =0 (oxo-ferryl) vibration in activated intermediates of heme enzymes. This mode is markedly sensitive to changes in the heme pocket environment. A study of variations among heme enzyme intermediates is beginning to provide a description of structure and dynamics in the active site during catalysis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.