The nephrotic syndrome is an easily recognized condition which is manifested by edema, albuminuria, hypoalbuminemia, and hyperlipemia. The characteristic histological lesion consists of thickening and splitting of the basement membrane of the glomerular tufts with secondary tubular degeneration and lipoid deposition.1 Renal-clearance
A previously undetected transverse ridge the fingernails of normal infants has been described as first appearing at the proximal nail at 4 to 6 weeks of age. The ridge grows out to the free edge of the nail by 14 weeks of age. The intent of this report is to call attention to the fact that the ridge exists. The clinical significance of this finding, if any, awaits more extensive observation.
In the May 1968 issue of Pediatrics you published an observation on transverse nail ridging in early infancy that I felt was original. However, subsequent correspondence, revealed that Dr. Bela Schick first described these ridges in 1908 (Jahrb. Kinderh., 67:146). This fact was kindly brought to my attention by Dr. Maarten S. Sibinga, who published observations on growth of fingernails in Pediatrics (24:225, 1959). It is obvious, therefore, that this observation was known to some neonatologists and careful observers for some time.
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