Increased concentrations of the soluble form of the interleukin 2 receptor have been observed in the sera of Crohn's disease and ulcerative colitis patients. In this study we have observed the spontaneous release of soluble interleukin 2 receptor by unstimulated, isolated normal and inflammatory bowel disease colonic lamina propria mononuclear cells. Lamina propria mononuclear cells from Crohn's disease patients (median=204 U/ml (interquartile range 126-396, n 17) secreted significantly (p<001) more soluble interleukin 2 receptor than normal controls (median= 124*5 U/ml (108-131), n 12). No statistically significant differences were seen between ulcerative colitis (median= 135 U/ml , n 20) and normal controls. Moreover, significantly (p<0-01) increased amounts of soluble interleukin 2 receptor were secreted by colonic diverticulitis lamina propria mononuclear cells (median=259 U/ml (149-282), n 15) which were used as disease specificity controls. Time course experiments showed that the majority of soluble interleukin 2 receptor was released by isolated lamina propria mononuclear cells in the first six days of culture.
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