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The time-varying flow is studied experimentally in an anatomically accurate model of the human airways from the mouth through several generations of bronchial branching. The airway geometry is obtained from the CT scan of a healthy adult male of normal height and build. The three-component, three-dimensional mean velocity field is obtained throughout the entire model using phase-locked Magnetic Resonance Velocimetry. A pulsatile pump drives a sinusoidal waveform (inhalation and exhalation) with frequency and stroke-length such that the mean trachea Reynolds number at peak inspiration is 4200 and the Womersley number is 7. Integral parameters are defined to quantify the degree of velocity profile non-uniformity (related to axial dispersion) and secondary flow strength (lateral dispersion). It is found that the extrathoracic airways significantly modify the tracheal flow and that the flow at the first bifurcation is highly asymmetric. The effect of flow oscillation is to produce time dependent flow features which are asymmetric with respect to the acceleration and deceleration periods surrounding peak inhalation and exhalation. This is most pronounced in regions of separation and on the secondary flow structure, which are sensitive to local attributes of the real anatomy. This is reflected in the integral parameters, which behave non-monotonically between successive bronchial generations. In general, the measured oscillatory flow in a realistic anatomy confirms many trends derived from idealized models but also possesses qualitatively different large scale flow structures as compared to idealized representations of the upper airways.

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Measurement techniques such as Magnetic Resonance Velocimety (MRV) and Magnetic Resonance Concentration (MRC) are useful for obtaining 3D time-averaged flow quantities in complex turbulent flows, but cannot measure turbulent correlations or near-wall data. In this work, we use highly resolved Large Eddy Simulations (LES) to complement the experiments and bypass those limitations. Coupling LES and magnetic resonance experimental techniques is especially advantageous in complex non-homogeneous flows because the 3D data allow for extensive validation, creating confidence that the simulation results portray a physically realistic flow. As such we can treat the simulation as data, which "enrich" the original MRI mean flow results. This approach is demonstrated using a cylindrical and inclined jet in crossflow with three distinct velocity ratios, r = 1, r = 1.5, and r = 2. The numerical mesh is highly refined in order for the subgrid scale models to have negligible contribution, and a systematic, iterative procedure is described to set inlet conditions. The validation of the mean flow data shows excellent agreement between simulation and experiments, which creates confidence that the LES data can be used to enrich the experiments with near-wall results and turbulent statistics. We also discuss some mean flow features and how they vary with velocity ratio, including wall concentration, the counter rotating vortex pair, and the in-hole velocity.

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