based screening study rather than a geographically based study such as the Coventry diabetes study.' About 10% of our sample was not registered with a local general practitioner because the subjects either had remained registered with practitioners outside Coventry or had no general practitioner. This was not surprising for an area in which 20% of the adult population leave and enter every year.The prevalences reported by us include extrapolations to take into account the incomplete responses to screening and to the glucose tolerance test. They suggested that 42% of white diabetics and 40% of Asian diabetics were undiagnosed in the community. The random sample included those aged over 80, and the two falsely negative subjects mentioned by Dr Yudkin were white women aged over 70 with fasting blood glucose concentrations of <5 0 mmol/l but concentrations after two hours >11 1 mmol/l. Glucose tolerance declines with age,' and as false negative results were found only in elderly white women we did not wish to include an estimate of the number of false negative results in the other groups until the survey was complete.We hope that the final results of the study will clarify these points further. D SIMMONS D R R WILLIAMSM J POWELL Sheikh Rashid Diabetes Unit,
La linfohistiocitosis hemofagocítica puede aparecer como complicación por hiperreactividad inmune en contexto de pérdida de tolerancia a estructuras propias como en las colagenopatías. Se presenta el caso de una mujer de 62 años de edad, con antecedente de artritis reumatoide, quien reúne criterios diagnósticos para enfermedad de Behçet. Tras complicaciones hematológicas y realización de estudios complementarios se documentan fagocitos con hiperreactividad medular como causa de citopenias, generando el diagnóstico de linfohistiocitosis hemofagocítica. Con el presente caso se pretende resaltar la asociación de alteraciones hematológicas e inflamatorias en pacientes con enfermedad autoinmune
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