Revista Hispanoamericana de Hernia S oc ied a d H i s p a n oa me r ic a n a d e H ernia P r o C h ir ug ia et S c i e n t i a www.grupoaran.com Original Tratamiento laparoscópico de la hernia paraestomal: indicaciones y manejo en la actualidad Laparoscopic treatment of parastomal hernia: indications and current use
Utilidad del abordaje laparoscópico en el manejo de las hernias laterales de la pared abdominal Laparoscopic approach for lateral abdominal wall hernias
There is accumulating evidence that the lower levels of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in the nasal epithelium of children may be related to a lower incidence of COVID-19 compared to adults. However, no direct evidence is available to support this hypothesis. In this study, we compared the transcript levels of ACE2 and TMPRSS2 in nasopharyngeal swabs (n=207) from children and adult members within COVID-19-exposed families and assessed their association with SARS-CoV-2 infection status. The expression of both genes was higher in adults compared to the children (n=115 adults and 92 children, p<0.05), but was not significantly different between COVID-19 positive and negative patients of all ages or within the same age groups. Using paired data, expression of both genes was significantly higher in COVID-19 positive adults compared to COVID-19 negative children (n=47 pairs; p<0.001) within the same families. ACE2 and TMPRSS2 expression is positively associated [OR:1.16(1.06-1.3) and 1.14(1.04-1.26) for ACE2 and TMPRSS2, respectively, p<0.001)] with SARS-CoV-2 infection status in the sub-group of families with COVID-19 positive adults and COVID-19 negative children, suggesting that children with lower levels of nasal ACE2 and TMPRSS2 are more likely to remain COVID-19 negative despite being exposed to a COVID-19-positive adult family member.
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