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Please cite this version:A. Svensson and Schön, T. B. (2017). A flexible state-space model for learning nonlinear dynamical systems. Automatica, 80, page 189-199.

Internet-based CBT could be useful for managing self-reported difficulties due to procrastination, both with and without the guidance of a therapist.

BackgroundProcrastination is a prevalent self-regulatory failure associated with stress and anxiety, decreased well-being, and poorer performance in school as well as work. One-fifth of the adult population and half of the student population describe themselves as chronic and severe procrastinators. However, despite the fact that it can become a debilitating condition, valid and reliable self-report measures for assessing the occurrence and severity of procrastination are lacking, particularly for use in a clinical context. The current study explored the usefulness of the Swedish version of three Internet-administered self-report measures for evaluating procrastination; the Pure Procrastination Scale, the Irrational Procrastination Scale, and the Susceptibility to Temptation Scale, all having good psychometric properties in English.MethodsIn total, 710 participants were recruited for a clinical trial of Internet-based cognitive behavior therapy for procrastination. All of the participants completed the scales as well as self-report measures of depression, anxiety, and quality of life. Principal Component Analysis was performed to assess the factor validity of the scales, and internal consistency and correlations between the scales were also determined. Intraclass Correlation Coefficient, Minimal Detectable Change, and Standard Error of Measurement were calculated for the Irrational Procrastination Scale.ResultsThe Swedish version of the scales have a similar factor structure as the English version, generated good internal consistencies, with Cronbach’s α ranging between .76 to .87, and were moderately to highly intercorrelated. The Irrational Procrastination Scale had an Intraclass Correlation Coefficient of .83, indicating excellent reliability. Furthermore, Standard Error of Measurement was 1.61, and Minimal Detectable Change was 4.47, suggesting that a change of almost five points on the scale is necessary to determine a reliable change in self-reported procrastination severity.ConclusionsThe current study revealed that the Pure Procrastination Scale, the Irrational Procrastination Scale, and the Susceptibility to Temptation Scale are both valid and reliable from a psychometric perspective, and that they might be used for assessing the occurrence and severity of procrastination via the Internet.Trial registrationThe current study is part of a clinical trial assessing the efficacy of Internet-based cognitive behavior therapy for procrastination, and was registered 04/22/2013 on ClinicalTrials.gov (NCT01842945).

Most existing traffic conflict indicators do not sufficiently take into account the severity of the injuries resulting from a collision had it occurred. Thus far, most of the indicators that have been developed express the severity of a traffic encounter as their proximity to a collision in terms of time or space. This paper presents the theoretical framework and the first implementation of Extended Delta-V as a measure of traffic conflict severity in site-based observations. It is derived from the concept of Delta-V as it is applied in crash reconstructions, which refers to the change of velocity experienced by a road user during a crash. The concept of Delta-V is recognised as an important predictor of crash outcome severity. The paper explains how the measure is operationalised within the context of traffic conflict observations. The Extended Delta-V traffic conflict measure integrates the proximity to a crash as well as the outcome severity in the event a crash would have taken place, which are both important dimensions in defining the severity of a traffic event. The results from a case study are presented in which a number of traffic conflict indicators are calculated for interactions between left turning vehicles and vehicles driving straight through a signalised intersection. The results suggest that the Extended Delta-V indicator seems to perform well at selecting the most severe traffic events. The paper discusses how the indicator overcomes a number of limitations of traditional measures of conflict severity. While this is a promising first step towards operationalising an improved measure of traffic conflict severity, additional research is needed to further develop and validate the indicator.

Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation and tumour neovascularisation can specifically attract stem cells to invasive gliomas. Injected stem cells engineered to produce anti-tumour substances have shown strong therapeutic effects in experimental glioma models. However, the potential caveats include the immunosuppressive functions of multipotent mesenchymal stromal cells, the contribution of stem cells to the pro-tumourigenic stroma, and the malignant transformation of implanted stem cells. In addition, it is not yet known which stem cell types and therapeutic genes will be most effective for the treatment of glioma patients. Here, we highlight the possibilities and problems for translating promising experimental findings in glioma models into the clinic.

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