Syntex Research I n s t i t u t e of Pharmaceutical Sciences 3401 H i 11 view Avenue Palo Alto, C a l i f o r n i a 94304 (41 5) 852-1 754 435 SILICONE ELASTOPIER TABLET. IV ( 7 ) N,R, A n d e r s o n , V.L. A n d e r s o n a n d G.E. P e c k , D r u g m, Dev. I n d . P h a r m . , 7 , 3 7 1 ( 1 9 8 1 ) -~( 8 ) G , Z o g r a f i , " W e t t i n g , A d h e s i o n a n d P o l y m e r i i C o a t i n g " , P r e s e n t a t i o n a t t h e A r d e n H o u s e ( 1 C o n f e r e n c e , F e b r u a r y , 1987. S( S! ( 9 ) R . L . offm man, J . C o l l o i d I n t e r f a c e S C i . , 50, i r ~ .-.--?.2E!*., (.!z,7?.12b cG411psraLure UoLr-easeu granule p a r t i c l e size; 2) granule geometric median diameter c o r r e l a t e d d i r e c t l y w i t h the polymer f r a c t i o n sprayed onto the granulation; 3) granulations w l t h high bulk density and per cent f i n e s generally produced much more f r i a b l e and s o f t e r tablets due t o t h e r e l a t i v e l y small polymer f r a c t i o n used i n the spray solutions; 4) a Small f r a c t i o n o f polymer sprayed onto the powder had r e s u l t e d i n a poor flowing granulation, delarnlnation and capplng durlng t a b l e t l n g , and subsequently a f a s t e r d i s s o l u t i o n r a t e (USP Paddle Apparatus). conditions, CR t a b l e t s can be produced from f l u l d bed granulations whlch show adequate d i s s o l u t i o n , hardness, and f r i a b i l i t y . With c e r t a i n 581 Copyright 0 1990 by Marcel Dekker, Inc. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Auckland on 11/03/14 For personal use only.