The unique photoluminescent properties of upconversion nanoparticles (UCNPs) have attracted worldwide research interest and inspired many bioanalytical applications. The anti‐Stokes emission with long luminescence lifetimes, narrow and multiple absorption and emission bands, and excellent photostability enable background‐free and multiplexed detection in deep tissues. So far, however, in vitro and in vivo applications of UCNPs are restricted to the laboratory use due to safety concerns. Possible harmful effects may originate from the chemical composition but also from the small size of UCNPs. Potential end users must rely on well‐founded safety data. Thus, a risk to benefit assessment of the envisioned combined therapeutic and diagnostic (“theranostic”) applications is fundamentally important to bridge the translational gap between laboratory and clinics. The COST Action CM1403 “The European Upconversion Network—From the Design of Photon‐Upconverting Nanomaterials to Biomedical Applications” integrates research on UCNPs ranging from fundamental materials synthesis and research, detection instrumentation, biofunctionalization, and bioassay development to toxicity testing. Such an interdisciplinary approach is necessary for a better and safer theranostic use of UCNPs. Here, the status of nanotoxicity research on UCNPs is compared to other nanomaterials, and routes for the translation of UCNPs into clinical applications are delineated.
Whenever Life Cycle Assessment (LCA) is used to assess the climate impact of buildings, those with high content of biobased materials result with the lowest impact.Traditional approaches to LCA fail to capture aspects such as biogenic carbon exchanges, their timing and the effects from carbon storage. This paper explores a prospective increase of biobased materials in Swedish buildings, using traditional and dynamic LCA to assess the climate impact effects of this increase. Three alternative designs are analysed; one without biobased material content, a CLT building and an alternative timber design with "increased bio". Different scenario setups explore the sensitivity to key assumptions such as the building's service life, end-of-life scenario, setting of forest sequestration before (growth) or after (regrowth) harvesting and time horizon of the dynamic LCA. Results show that increasing the biobased material content in a building reduces its climate impact when biogenic sequestration and emissions are accounted for using traditional or dynamic LCA in all the scenarios explored. The extent of these reductions is significantly sensitive to the endof-life scenario assumed, the timing of the forest growth or regrowth and the time horizon of the integrated global warming impact in a dynamic LCA. A time horizon longer than one hundred years is necessary if biogenic flows from forest carbon sequestration and the building's life cycle are accounted for. Further climate impact reductions can be obtained by keeping the biogenic carbon dioxide stored after end-of-life or by extending the building's service life, but the time horizon and impact allocation among different life cycles must be properly addressed.
Oxidative stress is a risk factor for chronic diseases and was previously shown to be independently associated with obesity. The authors investigated the relationship between body mass index (BMI), age and oxidative stress on 2190 subjects undergoing a health care examination. Total antioxidant status (TAS), total peroxides (TOC) and autoantibodies against oxidized LDL (oLAb) were used as oxidative stress biomarkers in addition to serum lipoproteins, bilirubin and uric acid. Gender-specific differences were observed for age, BMI, serum concentrations of bilirubin, low-density lipoprotein (LDL), uric acid and TAS, all of which were higher in males (p < 0.001), while high-density lipoprotein (HDL), HDL/LDL ratio and TOC were higher in females (p < 0.001). Total cholesterol (p < 0.05) and LDL were increased (p < 0.05), while HDL was decreased (p < 0.05) in overweight and obese subjects. This was accompanied by increased uric acid and TAS concentrations. Lowest oLAb titers were detected in obese subjects. In extremely obese subjects, increased TOC and decreased TAS were observed in spite of high uric acid levels. These results demonstrate that oxidative stress increases with increasing BMI and age, as a sequel to an impaired antioxidant status, the consumption of oLAbs, an increase of peroxides and uric acid and a disadvantaged lipid profile.
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