Our results indicate a high sensitivity of FET PET for detecting high-grade glioma in patients with neurological symptoms and recently observed brain lesions by MRI. In the setting of evaluating new brain lesions of unknown significance via FET PET a negative image can encourage a wait and see strategy-of course in accordance with the clinical picture and morphological imaging.
(99m)Tc-apcitide scintigraphy may be an easy and promising tool for the detection of acute clot formation in patients with DVT up to 17 days after the onset of clinical symptoms with a sensitivity of 87% and a specificity of 100%. However, it failed to demonstrate PE in 83% of examined patients with proven PE.
A 76-year-old man with prostate cancer pT2c N0 M0 R1 GS9 (4+5) operated 2009 and radiated postoperatively underwent restaging by Ga-PSMA-PET in January 2017 because of PSA rise at 0.44 ng/ml under medication with GnRH analogues. An intense focal uptake of the diffusely enlarged left adrenal gland was observed as the only pathological finding. Further evaluation by MRI imaging revealed a plump left adrenal gland with a relatively enlarged diameter of 2 cm and excluded tumor and nodular hyperplasia as well. Without any change of the therapeutic regime the patient presented in July 2017 with a PSA level of 0.05 ng/ml and no sign of cancer progress.
Background:
68Ga-PSMA is a widely useful PET/CT tracer for prostate cancer imaging. Being
a transmembrane protein acting as a glutamate carboxypeptidase enzyme, PSMA is highly expressed in
prostate cancer cells. PSMA can also be labeled with 64Cu, offering a longer half-life and different resolution
imaging. Several studies documented bio-distribution and pitfalls of 68Ga-PSMA as well as of 64Cu-
PSMA. No data are reported on differences between these two variants of PSMA. Our aim was to evaluate
physiological distribution of these two tracers and to analyze false positive cases.
Methods:
We examined tracer bio-distribution in prostate cancer patients with negative 68Ga-PSMA
PET/CT (n=20) and negative 64Ga-PSMA PET/CT (n=10). A diagnostic pitfall for each tracer was documented.
Results:
Bio-distribution of both tracers was similar, with some differences due to renal excretion of 68Ga-
PSMA and biliary excretion of 64Cu-PSMA. 68Ga-PSMA uptake was observed in sarcoidosis while 64Cu-
PSMA uptake was recorded in pneumonitis.
Discussion:
Both tracers may present similar bio-distribution in the human body, with similar uptake in
exocrine glands and high intestinal uptake. Similarly to other tracers, false positive cases cannot be excluded
in clinical practice.
Conclusion:
The knowledge of difference in bio-distribution between two tracers may help in interpretation
of PET data. Diagnostic pitfalls can be documented, due to the possibility of PSMA uptake in inflammation.
Our results are preliminary to future studies comparing diagnostic accuracies of 68Ga-PSMA
and 64Cu-PSMA.
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