This review summarizes the mechanisms of antibacterial action of green tea catechins, discussing the structure–activity relationship (SAR) studies for each mechanism.
A rhodiumA C H T U N G T R E N N U N G (III)-catalyzed amidation between benzoic acids and isocyanates via direct functionalization of an ortho C À H bond followed by intramolecular cyclization is described. This cascade cyclization affords N-substituted phthalimides in one step in 26-91% yields. The reaction is highly atom-economical, since no theoretical waste except for water is generated in the reaction.
A one-pot methodology for the synthesis of polyfunctionalized indole derivatives by a TiCl4/Et3N-promoted trimolecular condensation of aldehydes, indole heterocycles, and various activated carbonyl compounds is reported. Rationalization of these reactions and extension to other heterocyclic systems is also described.
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