Herein, we report the synthesis and structural characteristics of three tetrazole-containing compounds, 1-benzyl-1H-tetrazole (bntz), 1-benzyl-1H-tetrazol-5-amine (bntza) and 1-(4methoxybenzyl)-1H-tetrazol-5-amine (mbntza) and the corresponding silver(I) complexes of the general formula [Ag(NO3-O)(L-N4)2]n, L = bntz (1), bntza (2) and mbntza (3). Silver(I) complexes 1 -3 and 1-benzyl-1H-tetrazoles have been studied in detail by NMR, IR and UV-Vis spectroscopic methods and the structures of 1 and 2 have been determined by single-crystal Xray diffraction analysis. The results of these analyses revealed a monodentate coordination of the ligands to Ag(I) ion via the N4 tetrazole nitrogen. The antimicrobial potential of silver(I) complexes 1 -3 was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi, displaying their remarkable inhibiting activity with MIC (minimal inhibitory concentration) values in the range 2 -8 and 0.16 -1.25 μg/mL (3.8 -16.3 and 0.31 -2.15 μM), respectively. On the other hand, 1-benzyl-1H-tetrazoles used for the synthesis of the silver(I) complexes were not active against the investigated strains, suggesting that the activity of the complexes originates from the Ag(I) ion exclusively. Moreover, silver(I) complexes 1 -3 have good therapeutic potential, which can be deduced from their moderate cytotoxicity on the human fibroblast cell line MRC5, with IC50 values falling in the range 30 -60 μg/mL (57.7 -103.4 μM).
The y radiolysis of the following RCN compounds in aqueous solutions was studied at low doses (<10 krads): hydrogen cyanide, acetonitrile, propionitrile, malononitrile, and succinonitrile. The radiolytic products H2, H202, NH3, aldehydes, C02, and HN02 were determined in degassed or oxygenated solutions at pH's 2 and 6. The cyano group was found to be the main target of attack by the primary free-radical products of irradiated water. Its behavior was considered by taking into account the free-radical model of water radiolysis and the radiation chemical yields measured under various experimental conditions. The following rate constants were determined in competition experiments: k{H + HCN) = 3.6 X 107 M-1 sec-1, k(eeq~+ HCN) = 6.6 X 10s M-1 sec"1, k(OH + HCN) < 5 X 107 M"1 sec-1; k(H + CH3CN) = 3.5 X 106 7M"1 sec"1, k(eeq~+ CH3CN) = 2.5 X 107 M~l sec"1, k(OH + CH3CN) = 5.5 X 106 M"1 sec"1; k( + C2H5CN) = 1.0 X 107 M-1 sec-1, k(eeq~+ C2H5CN) = 1.0 X 10s M"1 sec-1. A:(OH + C2H5CN) = 7.3 X 107 M"1 sec"1; k(H + CH2(CN)2) = 1.6 X 107 M-1 sec"1, Ar(eeq-+ CH2(CN)2) = 7.1 X 103 M-1 sec"1; k(H + (CH2CN)2) = 1.3 X 107 M"1 sec"1, k(eeq" + (CH2CN)2) = 1.7 X 103 M-1 sec"1, k(OH + (CH2CN)2) = 3.0 107 M"1 sec"1. The correlation between Taft's * function and measured rate constants of eeq" + RCN reactions shows that the effect of the substituent R is mainly of the inductive type.
A facile decarbonylation reaction of a variety of aromatic and heteroaromatic aldehydes using maghemite-supported palladium catalyst has been developed. The magnetic properties of catalyst facilitated an easy and efficient recovery of the catalyst from the reaction mixture using an external magnet. It was found that the catalyst could be reused up to four consecutive catalytic runs without a significant change in activity. In addition, the catalyst was also very effective in the dehalogenation of aryl halides. This is the first report on efficient utilization of directly immobilized Pd on maghemite in decarbonylation and dehalogenation reactions.
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