A case of adverse reaction to propylthiouracil therapy in a child with thyrotoxic nodular goiter is reported. After 26 months of well tolerated therapy he had fever, joint pain, swelling of legs and evidence of pericarditis. Subsequently there appeared high grade fever, malaise, purpuricskin lesions, conjunctivitis, granulocytopenia, adenopathies and splenomegaly There were not clinical nor laboratory sums of associated intercurrent diseases. Complete remission of symptoms on withdrawal of propyl thiouracil allowed us to make a diagnosis of an adverse reaction to the drug with pericarditis, vasculitis and granulocytopenia. (
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.