Hydrophilic networks based on functionalized hyaluronic acid and on partially acetylated chitosan, respectively, have been obtained. In the case of hyaluronic acid (HA), primary amino functionalities have been introduced along the polysaccharide chains. The ensuing derivatives, i.e., HA-lysine (HA-K), HA-diamino pentane (HA-DAP), and HA-glycine-lysine (HA-GK), have been characterized by high field NMR spectroscopy. NMR 2D-DOSY experiments have allowed us to optimize the purification procedure. Chitosan was made soluble in water by partial acetylation. Cross-linking reactions have been performed using glutaraldehyde. The obtained networks have been qualitatively characterized by means of (13)C CP-MAS NMR technique. The hydrogels have been characterized also in terms of water uptake.

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A simple preparation of a new hydrosoluble paclitaxel bioconjugate 8, representing a new class of paclitaxel derivatives, is described. Bioconjugate 8 was obtained by coupling hyaluronic acid (2) to paclitaxel (1) by means of a 4‐hydroxybutanoic acid derived linker (Scheme 2).

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