In most occupational settings, several chemical agents are commonly found, and the associated exposure risk for workers must be assessed. For this purpose, air samples can be collected and analyzed. AltrexChimie is a web application that helps industrial hygienists in the organization of the air sampling strategy and in the subsequent phases of data management, analysis, and communication. AltrexChimie contains a database of more than 550 chemical substances and their respective French Occupational Exposure Limit Values (OELV): Custom OELVs can also be defined by the user. AltrexChimie helps with the definition of key features of the sampling strategy, in particular by promoting a methodology for the design of Similar Exposure Groups (SEGs). Once measurement data are entered, they can be analyzed to obtain exposure diagnostics. Data management features allow for the easy storage and retrieval of measurements, and comprehensive dashboards help industrial hygienists (IHs) in the communication of results. Finally, with AltrexChimie it is also possible to assess exposure to multiple chemical substances and their additive effects. While most free software applications for the assessment of chemical exposure focus on the statistical computation of specific indicators, AltrexChimie offers several tools to assist IHs in the exposure assessment workflow.
Surveys of the French working population estimate that approximately 15% of all workers may be exposed to at least three different chemical agents, but the most prevalent coexposure situations and their associated health risks remain relatively understudied. To characterize occupational coexposure situations in France, we extracted personal measurement data from COLCHIC and SCOLA, two large administrative occupation exposure databases. We selected 118 chemical agents that had ≥100 measurements with detected concentrations over the period 2010–2019, including 31 carcinogens (IARC groups 1, 2A, and 2B). We grouped measurements by work situations (WS, combination of sector, occupation, task, and year). We characterized the mixtures across WS using frequent itemset mining and association rules mining. The 275,213 measurements extracted came from 32,670 WS and encompassing 4692 unique mixtures. Workers in 32% of all WS were exposed to ≥2 agents (median 3 agents/WS) and 13% of all WS contained ≥2 carcinogens (median 2 carcinogens/WS). The most frequent coexposures were ethylbenzene-xylene (1550 WS), quartz-cristobalite (1417 WS), and toluene-xylene (1305 WS). Prevalent combinations of carcinogens also included hexavalent chromium-lead (368 WS) and benzene-ethylbenzene (314 WS). Wood dust (6% of WS exposed to at least one other agent) and asbestos (8%) had the least amount of WS coexposed with other agents. Tasks with the highest proportions of coexposure to carcinogens include electric arc welding (37% of WS with coexposure), polymerization and distillation (34%), and construction drilling and excavating (34%). Overall, the coexposure to multiple chemical agents, including carcinogens, was highly prevalent in the databases, and should be taken into account when assessing exposure risks in the workplace.
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