Cerebral venous thrombosis is an uncommon condition in the group of cerebrovascular diseases, usually affecting young individuals. Various risk factors are reported, including thrombophilia, connective tissue diseases, cancer, drugs and head trauma. It can manifest clinically by headache, focal deficits, visual disturbances and seizures, according to the site vascular involved. There are few cases reported in literature about the association of cerebral venous thrombosis with systemic lupus erythematosus. A case of a 34 year-old femalepatient is reported whose initial sign of cerebral venous thrombosis, confirmed by computed tomography and magnetic resonance angiography of the brain, occurred with generalized tonic-clonic seizures. Patient underwent extensive workup, filling the classification criteria for SLE, according to the Guidelines of the American College of Rheumatology, 1997. Patient received therapeutic anticoagulantion and immunosuppressive therapy, being referred to outpatient treatment with the Rheumatology clinic, without recurrence of seizures.
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